Evaluating the utility of N1,N12-diacetylspermine and N1,N8-diacetylspermidine in urine as tumor markers for breast and colorectal cancers |
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| Authors: | Yoshifumi Umemori Yui Ohe Kageaki Kuribayashi Naoki Tsuji Toshihiko Nishidate Hidekazu Kameshima Koichi Hirata Naoki Watanabe |
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| Institution: | 1. Division of Laboratory Diagnosis, Sapporo Medical University Hospital, Japan;2. Department of Clinical Laboratory Medicine, Sapporo Medical University School of Medicine, Japan;3. Department of Surgery, Sapporo Medical University School of Medicine, Japan;1. Department of Advanced Materials Science and Engineering, Chiba Institute of Technology, Narashino 275-8588, Japan;2. Institute for Solid State Physics, The University of Tokyo, Kashiwa 277-8581, Japan;1. Clinical Pharmacology Research Center & Translational Medicine Centre, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100032, China;2. Tianjin Chase Sun Pharmaceutical Co. LTD, Tianjin 301700, China |
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| Abstract: | BackgroundAmong natural polyamines, the concentrations of the diacetylated form of spermine and spermidine increase in the urine of patients with cancer. We evaluated the utility of urinary N1,N12-diacetylspermine (DiAcSpm) and N1,N8-diacetylspermidine (DiAcSpd) as tumor markers for breast and colorectal cancers.MethodsUrinary DiAcSpm and DiAcSpd concentrations were measured by an enzyme-linked immunosorbent assay. Urine and serum samples were collected from 33 and 28 patients with colorectal and breast cancers, respectively. The sensitivity of urine samples to DiAcSpm and DiAcSpd concentrations was compared with serum concentrations of carcinoembryonic antigen (CEA) and carbohydrate antigen CA 15-3 in breast cancer patients and with serum concentrations of CEA and CA 19-9 in colorectal cancer patients, respectively.ResultsIn breast cancer patients, the sensitivity of DiAcSpm and DiAcSpd was 46.4% and 14.2%, respectively, which was higher than that of CEA and CA 15-3. In patients with colorectal cancer, the sensitivity of DiAcSpm and DiAcSpd was 69.6% and 36.3%, respectively. CEA was the second sensitive marker and CA 19-9 was the least sensitive marker in these patients.ConclusionDiAcSpm is a highly sensitive tumor marker. DiAcSpm can serve as a powerful tool in settings such as initial screening for cancers in routine health examination. |
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