急性脑梗死应用阿托伐他汀联合甘露醇治疗的效果分析

目的探讨阿托伐他汀联合甘露醇治疗急性脑梗死的临床效果。方法108例急性脑梗死患者,采用随机数字表法分为对照组和研究组,各54例。对照组应用甘露醇及常规对症治疗,研究组在对照组基础上联合阿托伐他汀治疗。对比两组治疗前后超敏C反应蛋白(hs-CRP)、基质金属蛋白酶9(MMP-9)、D-二聚体、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平及治疗效果、不良反应发生情况。结果研究组的治疗总有效率92.6%高于对照组的77.8%,差异具有统计学意义(P<0.05)。治疗前,两组TG、TC、LDL-C、HDL-C水平对比差异无统计学意义(P>0.05);治疗后,研究组的TG(1.82±0.38)mmol/L、TC(4.03±0.66)mmol/L、LDL-C(2.05±0.39)mmol/L均低于对照组的(2.19±0.47)、(6.01±0.71)、(2.44±0.41)mmol/L,HDL-C(1.48±0.36)mmol/L高于对照组的(1.33±0.37)mmol/L,差异具有统计学意义(P<0.05)。治疗前,两组hs-CRP、MMP-9、D-二聚体水平对比,差异无统计学意义(P>0.05);治疗后,研究组hs-CRP、MMP-9、D-二聚体水平低对照组,差异具有统计学意义(P<0.05)。两组不良反应发生率对比差异无统计学意义(P>0.05)。结论对急性脑梗死应用阿托伐他汀联合甘露醇治疗效果理想,能够更好的降低血脂及炎性因子水平,且不会增加不良反应的发生,用药安全性高,值得临床进一步推广应用。

Efficacy of atorvastatin combined with mannitol in patients with acute cerebral infarction

Objective To discuss the clinical effect of atorvastatin combined with mannitol in patients with acute cerebral infarction.Methods A total of 108 patients with acute cerebral infarction were divided into control group and research group according to random numerical table,with 54 cases in each group.The control group was treated with mannitol and conventional symptomatic therapy,and the research group was treated with atorvastatin on the basis of the control group.The hypersensitive C-reactive protein(hs-CRP),matrix metalloproteinase 9(MMP-9),D-Dimer,triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)level before and after treatment,therapeutic effect,and occurrence of adverse reactions were compared between the two groups.Results The total effective rate 92.6%of the research group was higher than 77.8%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in levels of TG,TC,LDL-C and HDL-C between the two groups(P>0.05).After treatment,the TG(1.82±0.38)mmol/L,TC(4.03±0.66)mmol/L and LDL-C(2.05±0.39)mmol/L of the research group were all lower than(2.19±0.47),(6.01±0.71)and(2.44±0.41)mmol/L of the control group,and HDL-C(1.48±0.36)mmol/L was higher than(1.33±0.37)mmol/L of the control group.All the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in levels of hs-CRP,MMP-9 and D-Dimer between the two groups(P>0.05).After treatment,the levels of hs-CRP,MMP-9 and D-Dimer of the research group were lower than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in incidence of adverse reactions between the two groups(P>0.05).Conclusion Combination of atorvastatin and mannitol has an ideal effect in the treatment of acute cerebral infarction,which can better reduce the level of blood lipids and inflammatory factors without increasing the occurrence of adverse reactions.The medication is safe and worthy of further clinical promotion and application.