HDL 2 Particles are associated with hyperglycaemia,lower PON1 activity and oxidative stress in type 2 diabetes mellitus patients |
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| Authors: | Aleksandra Stefanovi? Jelena Kotur-Stevuljevi? Slavica Spasi? Jelena Veki? Aleksandra Zeljkovi? Vesna Spasojevi?-Kalimanovska Zorana Jeli?-Ivanovi? |
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| Institution: | 1. Department of Cardiology, Heart Hospital, Hamad Medical Corporation, PO Box 3050, Doha, Qatar;2. King Fahad Cardiac Centre, College of Medicine, King Saud University, 11472, Riyadh, Saudi Arabia;3. Department of Clinical Medicine, Weill Cornell Medical School, 24144, Doha, Qatar;4. Department of Medicine, Cardiology Unit, Ahmed Maher Teaching Hospital, Cairo, Egypt;5. Department of Cardiology, Royal Hospital, Muscat, Oman;6. Department of Cardiology, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates;7. Department of Cardiology, Mohammed Bin Khalifa Cardiac Center, Manama, Bahrain;8. Department of Cardiology, Faculty of Medicine, Sana''a University, Sana''a, Yemen;9. Saud Al-Babtain Cardiac Centre, 11850, Dammam, Saudi Arabia;10. Medical Research Center, Hamad Medical Corporation, PO Box 3050, Doha, Qatar;11. Department of Non-communicable Diseases, Ministry of Health, Muscat, Oman;3. Divisions of Preventive Medicine and Nutrition and Columbia University College of Physicians and Surgeons, New York, New York 10032;4. Institute of Systems Biomedicine, Peking University Health Science Center, 100083 Beijing, China,;6. Gladstone Institute of Cardiovascular Disease and Departments of Medicine and Biochemistry and Biophysics, University of California, San Francisco, California 94158,;5. Department of Geriatrics, Affiliated Provincial Hospital, Anhui Medical University, 230001 Hefei, China,;12. Astra-Zeneca Company, 431 50 Mölndal, Sweden,;8. Department of Medical Sciences, Uppsala University, 751 05 Uppsala, Sweden, and;9. Division of Endocrinology, Diabetes, and Metabolism, New York University Langone School of Medicine, New York, New York 10016;3. From the Department of Biology and;5. the Program in Molecular Biophysics, Johns Hopkins University, Baltimore, Maryland 21218,;4. the Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, and;6. the Department of Pathology, Baylor College of Medicine, Houston, Texas 77030 |
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| Abstract: | ObjectivesIn this study we examined the relationship of oxidative stress and hyperglycaemia to antioxidative capacity of high-density cholesterol (HDL-C) particles in type 2 diabetes mellitus (DM).Design and methodsOxidative stress status parameters (superoxide anion (O2?), superoxide dismutase (SOD) activity and paraoxonase (PON1) status were assessed in 114 patients with type 2 DM and 91 healthy subjects. HDL particle diameters were determined by non-denaturing polyacrylamide gradient (3–31%) gel electrophoresis.ResultsPatients had significantly higher concentrations of oxidative stress parameter O2?(p < 0.001) and antioxidative defence, SOD activity (p < 0.001). Paraoxonase activity was significantly lower in diabetics (p < 0.001). The PON1192 phenotype distribution among study groups was not significantly different. HDL 3 phenotype was significantly prevalent among patients (p < 0.001). Paraoxonase activity was significantly lower in patients with predominantly HDL 2 particles than in controls.ConclusionsThe results of our current study indicate that the diabetic HDL 2 phenotype is associated with hyperglycaemia, lower PON1 activity and elevated oxidative stress. |
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