阻塞性睡眠呼吸暂停心血管相关血清学标志物研究进展

阻塞性睡眠呼吸暂停（OSA）最常见的临床症状是夜间睡眠打鼾伴呼吸暂停，以慢性间歇性缺氧、高碳酸血症、反复微觉醒和睡眠结构紊乱为病理生理基础，是心血管疾病的源头疾病和危险因素。在临床实践中，多导睡眠监测仍是确诊OSA的金标准，但是受多导睡眠监测局限性、需专业的睡眠医师阅读报告等诸多因素的影响，导致多数患者诊治延迟。因此，目前研究热点是探寻一种简易、便捷的血清学标志物，从OSA患者中筛选心血管疾病高危患者，实现早期防治、精准治疗。

Development of cardiovascular related serologic markers for obstructive sleep apnea

Obstructive sleep apnea (OSA), the most common clinical symptom of which is nocturnal sleep snoring with apnea, is pathophysiologically based on chronic intermittent hypoxia, hypercapnia, recurrent micro arousals, and disturbed sleep architecture and is a source of cardiovascular disease and risk factor.In clinical practice, polysomnography remains the gold standard for the diagnosis of OSA, but many factors, such as the limitations of polysomnography and the need for specialized sleep physician reading reports, contribute to the delay in the diagnosis and treatment of most patients.Therefore, the current research hotspot is to ask an easy and convenient serological marker to screen patients at high risk of CVD from OSA patients to achieve early prevention and precision treatment.