Depletion of Coagulation Factors in Drug-Resistant Plasmodium Falciparum Malaria |
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| Authors: | DENNIS, LEWIS H. EICHELBERGER, JAMES W. INMAN, MAX M. CONRAD, MARCEL E. |
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| Affiliation: | 1 Division of Medicine, Walter Reed Army Institute of Research, and Departmentof Medicine, Walter Reed General Hospital, Washington, D. C.
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| Abstract: | United States soldiers with acute relapsed P. falciparum malaria had accelerated intravascular coagulation which was manifested by thrombocytopenia, a prolonged prothrombin time and partial thromboplastin time, a decrease in multiple coagulation factors, and evidence of decreased plasminogenactivation with an accumulation of fibrinogen breakdown products in theblood. These changes may be important in the pathophysiology of malariaand cause the hemorrhage and thrombosis found in many organs of patientsdying with falciparum malaria. Submitted on August 25, 1966 Accepted on November 4, 1966 |
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