Tyrosine Hydroxylase and Dopamine D4 Receptor Allelic Distribution in Scandinavian Chronic Alcoholics |
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| Authors: | T. Geijer,E. Jö nsson,J. Neiman,M.-L. Person,S. Brené ,A. Gyllander,G. Sedvall,U. Rydberg,D. Wasserman,L. Terenius |
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| Affiliation: | Department of Clinical Neuroscience (T.G., E.J., J.N., S.B., A.G., G.S., U.R., L.T.);Department of Clinical Neuroscience and Family Medicine, Section of Psychiatry (M.-L.P.), Huddinge University Hospital;and the National and Stockholm County Council Centre for Suicide Research and Prevention, National Institute for Psychosocial Factors and Health (M.-L.P., D.W.), Karolinska Institute, Stockholm, Sweden. |
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| Abstract: | Associations of polymorphic genetic markers at the tyrosine hydroxylase (TH) and dopamine D4 receptor (DRD4) loci were examined in Scandinavian chronic alcoholics ( n = 72) and control subjects ( n = 67). Patients were divided into subgroups with regard to the presence of parental alcoholism and age of onset. Neither the TH nor the DRD4 allele distributions were significantly different when alcoholic samples were compared with control subjects. However, a tendency to high prevalence for 1 of the 5 TH alleles assayed (TH-K3) was observed in a subsample of 44 alcoholics characterized by late onset when compared with control subjects (27.3% vs. 10.6%, p = 0.041). Results suggest that no major influence on alcoholism is exerted through genes associated with the DRD4 or TH allelic markers examined. |
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| Keywords: | Tyrosine Hydroxylase Dopamine D4 Receptor Genetics Polymorphism Alcoholism |
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