| 超声二维斑点追踪成像技术评价大鼠急性心肌梗死后局部心肌存活性 |
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| 引用本文： | 付倩,谢明星,王新房,吕清,方凌云,王静,袁莉,程龙,项飞翔. 超声二维斑点追踪成像技术评价大鼠急性心肌梗死后局部心肌存活性[J]. 中国医学影像技术, 2010, 26(4): 623-626 |
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| 作者姓名： | 付倩 谢明星 王新房 吕清 方凌云 王静 袁莉 程龙 项飞翔 |
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| 作者单位： | 1. 华中科技大学同济医学院附属协和医院超声影像科,湖北,武汉,430022
2. 华中科技大学同济医学院附属协和医院心血管外科,湖北,武汉,430022 |
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| 摘 要： | 目的 探讨超声二维斑点追踪成像技术评价大鼠急性心肌梗死后局部心肌存活性的应用价值.方法 20只Wistar大鼠随机分为急性心肌梗死组和假手术组,每组10只.于基础状态和恢复灌注24 h后对各组大鼠行超声心动图检查,记录左心室乳头肌短轴高帧频二维图像,测量节段心肌的收缩期峰值径向应变(PRS)、环向应变(PCS),并采用解剖M型超声测量左心室舒张末期内径(LVID_d)、左心室收缩末期内径(LVID_s)、短轴缩短率(FS)、射血分数(EF)和室壁增厚率(TR).实验结束后取大鼠心脏行左心室乳头肌短轴TTC染色并计算节段心肌的梗死面积(AN).以TTC染色作为金标准,ROC曲线分析上述二维应变及TR参数评价梗死节段的准确性.结果 ①与心肌梗死组基础状态及假手术组术后相比,心肌梗死组术后的LVID_d和LVID_s值均明显增加,FS、EF和前间隔TR值均明显降低(P<0.05);②与心肌梗死组基础状态及假手术组术后相比,心肌梗死组术后的前间隔、前壁、前侧壁、后侧壁和后间隔的PRS及PCS值均明显减低,心肌梗死组术后前间隔、前壁和前侧壁的PRS及PCS值明显低于其他节段(P<0.05);③以TTC染色所得节段心肌AN>50%为梗死节段,ROC曲线分析显示PCS为判断梗死心肌的最佳指标,PCS值为临界值(-6.14%)时诊断梗死心肌的敏感度为93.75%,特异度为90.91%.结论 超声二维斑点追踪成像技术能准确量化局部心肌功能.
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| 关 键 词： | 超声心动描记术 心室功能,左 心肌梗死 二维应变 |
| 收稿时间： | 2009-10-19 |
| 修稿时间： | 2009-12-21 |
Evaluation of regional myocardial viability in rats after acute myocardial infarction with two-dimensional speckle tracking imaging |
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| FU Qian,XIE Ming-xing,WANG Xin-fang,LV Qing,FANG Ling-yun,WANG Jing,YUAN Li,CHENG Long and XIANG Fei-xiang. Evaluation of regional myocardial viability in rats after acute myocardial infarction with two-dimensional speckle tracking imaging[J]. Chinese Journal of Medical Imaging Technology, 2010, 26(4): 623-626 |
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| Authors: | FU Qian XIE Ming-xing WANG Xin-fang LV Qing FANG Ling-yun WANG Jing YUAN Li CHENG Long XIANG Fei-xiang |
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| Affiliation: | Department of Ultrasonography,;Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Cardiovascular Surgery, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China;Department of Ultrasonography, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China |
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| Abstract: | Objective To observe the value of two-dimensional speckle tracking imaging (2D-STI) in assessing regional myocardial viability of rats after acute myocardial infarction. Methods Twenty Wistar rats were randomly divided into acute myocardial infarction group and sham-operation group (each n=10). Echocardiography was performed at baseline and 24 h after reperfusion. High frame rate two-dimensional images were recorded from the left ventricular short-axis views at the papillary muscle level. Peak radial strain... |
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| Keywords: | Echocardiography Ventricular function,left Myocardial infarction Two-dimensional strain |
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