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Formation of inositol phosphates mediated by M3 muscarinic receptors in type-1 and type-2 astrocytes from neonatal rat cerebral cortex |
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| Authors: | Hiroki Kondou Naoyuki Inagaki Hiroyuki Fukui |
| Affiliation: | Department of Pharmacology II, Faculty of Medicine, Osaka University, 2-2 Yamadaoka, Suita 565, Japan |
| Abstract: | Muscarinic receptor subtype in type-1 and type-2 astrocytes from rat neonalal cerebral cortex was examined for carbachol-elicited inositol phosphate (IP) formation. The formation of carbachol-elicited IP was inhibited by various muscarinic antagonists in the following relative order of potency: 4-DAMP atropine pirenzepine > AF-DX 116. This pharmacological profile suggests that the activation of the M3 muscarinic receptor subtype is responsible for the stimulation of IP formation in both astrocytes. |
| Keywords: | Astrocyte Inositol phosphate Carbachol Muscarinic receptor Receptor subtype Muscarinic antagonist |
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