| IL－2和sIL－2R在哮喘发病中的意义探讨 |
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| 引用本文： | 诸葛坚,王立人,毕爱华,刘光辉. IL－2和sIL－2R在哮喘发病中的意义探讨[J]. 免疫学杂志, 1994, 0(4) |
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| 作者姓名： | 诸葛坚 王立人 毕爱华 刘光辉 |
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| 作者单位： | 同济医科大学免疫学教研室，同济医院变态反应科 |
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| 摘 要： | 为了探讨ＩＬ－２和ｓＩＬ－２Ｒ在哮喘发病中的意义，对３６例哮喘患者外周血单个核细胞（ＰＢＭＣ）诱生ＩＬ－２水平和血浆ｓＩＬ－２Ｒ水平进行了检测，同时以支气管炎患者与正常人作对照。结果表明，ＰＢＭｃ诱生的ＩＬ－２活性哮喘组高于正常对照组（ｐ＜０．０５）；血浆ｓＩＬ－２Ｒ水平哮喘组高于支气管炎和正常组（ｐ＜０．０１），后两者差异无显著性。以上结果表明，哮喘发病中存在着Ｔ细胞的活化，ＩＬ－２／ＩＬ－２Ｒ在哮喘发病中起作用。
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| 关 键 词： | 哮喘，IL－2，sIL－2R |
Investigation of the Role of Interleukin-2 and Soluble Interleukin-2 Receptorin the Pathogenesis of Asthma |
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| Zhuge Jian, Wang Liren,Bi Aihua. Investigation of the Role of Interleukin-2 and Soluble Interleukin-2 Receptorin the Pathogenesis of Asthma[J]. Immunological Journal, 1994, 0(4) |
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| Authors: | Zhuge Jian Wang Liren Bi Aihua |
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| Abstract: | In order to investigate the role of IL-2 and sIL-2R in the pathogenesis of asthma,induced IL-2 activity insupernatant of peripheral blood mononuclear cells(PBMC) and sIL-2R levels in plasma were determined in 36 patientswith asthma, 32 patients with bronchitis and 54 normal controls.The teslts showed that the induced IL-2 activity in su-pernatant of PBMC incteased in patients with asthma and bronchitis in comparison with normal controls(p<0.05).andsIL-2R levels plasma of patients with asthma were higher than that of in patients with bronchitis and normal controls(p<0. 01).the difference between latter two groupe has no significance. These observations provide further evidence that Tlymphocyte phocyte activation is an important factor in the pathogenesis of asthma,IL-2 and sIL-2R may play a role in inflam-mation of sathma. |
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| Keywords: | Asthma Inlerleukin-2 Soluble interleukin-2 receptor |
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