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Der Einfluß des Druckes in den Coronararterien auf die Druck-Volumen-Beziehung des linken Ventrikels
Authors:Ph. Greuner-Sigusch  G. Greuner  C. Morgenstern
Affiliation:(1) Physiologisches Institut der Universität Düsseldorf, Düsseldorf, Deutschland
Abstract:Summary The influence of coronary perfusion pressure on the pressure-volume relation of the left ventricle was investigated in isolated and arrested cat and dog hearts. The left coronary artery was separately perfused.The duration of the experiment, edema of the myocardium and the inflow through the Thebesian vessels complicate the measurement of the pressure-volume relation.Excluding these factors the experiments prove, that coronary perfusion pressure is a determinant of the pressure-volume relation of the heart. Increasing coronary pressure shifts the relation between pressure and volume upward and to the left (Figs. 3 and 4).
$$frac{{Delta P}}{{Delta V}}$$
increases with increasing coronary perfusion pressure, while the elasticity modulus
$$E = frac{{Delta P}}{{Delta V}} times V$$
is not changed (Fig. 5).
Keywords:Coronary Perfusion Pressure  Pressure-Volume Relation  Myocardial Edema  Myocardial Stiffness
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