Anti-apoptotic gene transcription signature of salivary gland neoplasms |
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| Authors: | Carolina Cavaliéri Gomes Vanessa Fátima Bernardes Marina Gonçalves Diniz Luiz De Marco Ricardo Santiago Gomez |
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| Affiliation: | (1) Department of Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;(2) Department of Oral Surgery and Pathology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil;(3) Department of Surgery, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil |
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| Abstract: | Background Development of accurate therapeutic approaches to salivary gland neoplasms depends on better understanding of their molecular pathogenesis. Tumour growth is regulated by the balance between proliferation and apoptosis. Few studies have investigated apoptosis in salivary tumours relying almost exclusively on immunohistochemistry or TUNEL assay. Furthermore, there is no information regarding the mRNA expression profile of apoptotic genes in salivary tumors. Our objective was to investigate the quantitative expression of BCL-2 (anti-apoptotic), BAX and Caspase3 (pro-apoptotic genes) mRNAs in salivary gland neoplasms and examine the association of these data with tumour size, proliferative activity and p53 staining (parameters associated with a poor prognosis of salivary tumours patients). |
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