孕妇血、脐血、乳汁的乙型肝炎病毒DNA水平及其相关性

【目的】探讨乙型肝炎病毒 (HBV)母婴垂直传播的规律 ,为预防和阻断HBV的母婴传播提供依据。【方法】对 6 8例HBsAg阳性孕产妇以荧光定量PCR方法检测其静脉血、脐血、乳汁HBVDNA含量并分析其相关性。【结果】孕妇血与脐血HBVDNA的含量相关系数为 0 34 46 (P =0 0 0 8) ,孕妇血与乳汁HBVDNA的含量的相关系数为 0 144 9(P =0 2 6 1)。【结论】孕妇血HBVDNA水平与脐血HBVDNA水平呈正相关 ,降低孕妇血HBVDNA水平 ,有利于控制HBV宫内感染 ;对HBsAg阳性产妇应检测乳汁HBVDNA ,以便指导母乳喂养。

The Relative Study of Hepatitise B Virus DNA in Maternal blood Umbilical Blood and Breastmilk

Objective To study the rule of vertical transmission of hepatitise B virus (HBV) in order to prevent and stop the transmission. Methods To detect HBV DNA in venous blood, umbilical blood and breastmilk of 68 HBsAg positive parturients by FQ PCR and analyse their relativity. Results The relative ratio between the value of venous HBV DNA and that of umbilical HBV DNA was 0 3446(P=0 008). The relative ratio between the value of venous HBV DNA and that of breastmilk HBV DNA was 0 1449 (P=0 261). Conclusion HBV DNA level in the umbilical blood is positive relative to that in the venous blood. Decrease of the HBV DNA level in venous blood would be helpful to control HBV intrauterine transmission. Detection of HBV DNA in breastmilk should be done to HBV carrier mothers in order to conduct breasfeeding.