埃索美拉唑治疗老年人非甾体抗炎药相关性消化性溃疡出血的临床疗效探讨

目的：研究埃索美拉唑治疗老年人非甾体抗炎药相关性消化性溃疡出血的临床疗效。方法：将非甾体抗炎药相关性消化性溃疡出血患者纳入研究,并随机分为观察组（埃索美拉唑治疗）和对照组（奥美拉唑治疗）,比较两组患者的基线资料,观察溃疡出血疗效、腹痛缓解情况、溃疡愈合情况以及不良反应情况。结果：1两组患者基线资料相比,无显著差异;2观察组溃疡出血的显效率为60.0%（42/70）、有效率为34.3%（24/70）,整体治疗效果优于对照组,其差异有统计学意义（x2=8.384,P〈0.05）;3两组患者腹痛及溃疡愈合情况比较,无显著差异;4两组患者治疗过程中均无严重不良反应。结论：相比奥美拉唑治疗,埃索美拉唑对腹痛缓解和溃疡愈合的疗效相当,且对于溃疡出血的治疗更为有效,是治疗非甾体抗炎药相关性消化性溃疡出血的有效方法。

Research on effect of esomeprazole in treating elderly patients with NSAIDs correlated peptic ulcer bleeding

Objective： To study the effect of esomeprazole in treating elderly patients with NSAIDs correlated peptic ulcer bleeding. Methods： Patients with NSAIDs correlated peptic ulcer bleeding in our hospital from January, 2010-December, 2012 were enrolled and randomly divided into observation group given esomeprazole and control group given omeprazole. Then the baseline data were surveyed and effect of ulcer bleeding, condition of abdominal pain alleviation and ulcer ulcer, adverse reaction cases were observed. Results： （1）there were no significant difference between the baseline data of two group; （P〉0.05）; （2）in observation group, excellence rate was 42/70（60% ）, effective rate was 24/70（54.5%）, the overall treatment effect was better than that of control group, the difference had statistical significant（P〈0.05）; （5）there were no significant difference between two group of abdominal pain and ulcer healing; （4） during treatment, there were no serious adverse reactions in the two groups. Conclusion： Compared with omeprazole, esomeprazole has equal effect on abdominal pain relief and ulcer healing, and it is much more effective in treating elderly patients with NSAIDs correlated peptic ulcer bleeding.