纳洛酮对中、重型颅脑损伤血浆内皮素的影响

目的：观察纳洛酮对中、重度型颅脑损伤血浆内皮素（ET）的影响。方法：选择中、重型颅脑损伤患者85例，均为损伤后24h内入院，GCS3－12分，随机分为纳洛酮治疗组和NS对照组，分别于治疗前及治疗后不同时期，以放免法检测其血浆ET水平，并选择同期健康献血者30例，行ET检测，结果：中、重型颅脑损伤患者24h内已出现血浆ET含量显著增加，纳洛酮治疗后ET水平明显下降（P＜0．01），GCS评分明显提高（P＜0．01），与NS对照相比有统计学差异（P＜0．01）。结论：纳洛酮可降低颅脑损伤患者血浆ET水平。

Effects of naloxone on plasma endothelin in patients with moderate or severe craniocerebral injury

AIM: To explore the effects of naloxone on plasma endothelin (ET) in patients with moderate or severe craniocerebral injury. METHODS: Eighty five patients with moderate or severe craniocerebral injury were divided randomly into the naloxone treated group and the NS controlled group, who admitted to the hospital within 24 h after injury and whose GCS was 3 12. Plasma ET was measured with RIA before and after treatment. And the donor's blood samples were also measured at the same period. RESULTS: Plasma ET was significantly increased in moderate or severe craniocerebral injury patients within 24 h after injury. ET was decreased ( P <0 01) and GCS was increased ( P <0 01) after the treatment of naloxone. There was a signiciant difference compared with the NS group ( P <0 01). CONCLUSION: Naloxone can act as a practical ET antagonist in clinical practice for it can decrease the plasma ET.