应激生活事件和斑秃发生风险的相关性调查

目的调查斑秃患者发病和精神因素的相关性,揭示精神因素在斑秃发病中的潜在作用。方法收集2008年3月至2009年3月西南医院皮肤科确诊斑秃患者和健康人群,采用病例对照研究方法,记录研究对象的流行病学情况,采用Thomas Holmes和Richard Rahe社会再适应量表调查斑秃患者发病6个月前应激生活事件及健康对照填表前6个月的应激生活事件,统计学分析斑秃发病和应激生活事件的相关性。结果斑秃患者应激生活事件的发生率与患者性别及斑秃类型无统计学差异(P>0.05)。51.34%的斑秃患者在发病前6个月经历过2项以上应激生活事件,32.05%的对照在填表前6个月经历过2项以上应激生活事件,两者差异有统计学意义(P<0.01)。主要的应激生活事件为睡眠改变、个人习惯改变、居住环境改变、家庭问题、工作问题、学习问题和财政问题。斑秃患者组的SRRS评分高于健康对照组(P<0.01),斑秃患者发病前应激状态明显高于健康对照。经多因素Logistic回归分析,睡眠改变、学习问题、个人习惯改变和家庭问题应激生活事件是斑秃发生的危险因素。结论应激生活事件对斑秃的发生起着一定作用,应激诱发斑秃机制将有助于斑秃防治措施的开发。

Correlation of stressful life events and risk of alopecia areata

Objective To investigate the correlation of psychosocial factors with risk of alopecia areata(AA).Methods Case-control study was performed on 261 AA patients identified in our department from March 2008 to March 2009,and 259 age and sex-matched health controls from Southwest Hospital.Data for clinic and demographic factors were obtained by standard approaches.Stressful situations were evaluated by using Holmes and Rahe's social readjustment rating scale(SRRS) for the patients in the past 6 months of AA onse...