p73蛋白在卵巢上皮性肿瘤中的表达

目的 :研究卵巢上皮性肿瘤中p73蛋白的表达 ,探讨其在卵巢肿瘤发生、发展中的作用。方法 :应用免疫组化S P法检测p73蛋白在 2 0例良性、 9例交界性、 31例恶性卵巢上皮性肿瘤中的表达。结果 :p73蛋白的阳性表达率分别为 :良性卵巢上皮性肿瘤无表达 (0 / 2 0 ) ,交界性卵巢上皮性肿瘤 2 2 . 2 2 % (2 / 9) ,原发性卵巢上皮性癌 4 1. 94 % (13/ 31) ,差异有显著性 (P <0 . 0 5 )。恶性肿瘤组内p73蛋白的表达与组织分化有关 ,在低分化癌中有较高表达 ,差异有显著性 (P <0 . 0 5 ) ;p73蛋白的表达与不同临床分期无关 (P >0 .0 5 )。结论 :p73基因以高表达方式参与卵巢恶性上皮性肿瘤的发生 ,在卵巢癌发生的分子机制中起作用

A Study on Expression of p73 Protein in Ovarian Epithelial Neoplasms

Objective: To investigate the expression of p73 and to analyze its role in ovarian epithelial tumors. Methods: The expression of p73 protein in 20 cases of benign ovarian tumor,9 cases of borderline ovarian tumor and 31 cases of epithelial ovarian carcinoma was analyzed with immunohistochemical technique. Results: The expression of p73 was not positive in benign ovarian tumors(0/20), but positive expression was found in 2/9 (22.22%) of borderline trmors and 13/31 (41.94%) of primary ovarian epithelial malignant tumors. There were obvious differences of p73 expression among the three groups (P<0.05). The expression of p73 was negatively correlated with the differentiation of malignant tumor (P<0.05)and it had higher expression in cases of lower differentiation. There was no difference of p73 expression among cases with different differentiation (P>0.05). Conclusion: p73 gene takes part in the development of ovarian epithelial tumors. It might play an important role in the genesis of ovarian cancer.