| 橙皮苷对STZ糖尿病大鼠肾脏功能和形态的影响 |
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| 引用本文： | 王新嘉 何国芬. 橙皮苷对STZ糖尿病大鼠肾脏功能和形态的影响[J]. 中华内分泌代谢杂志, 1996, 12(1): 34-36 |
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| 作者姓名： | 王新嘉 何国芬 |
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| 作者单位： | 山西医学院第一附属医院内分泌科，山西医学院第一附属医院内分泌科，山西医学院第一附属医院内分泌科，山西医学院第二附属医院，山西医学院第二附属医院 030001太原研究生山西医学院第二附属医院，030001太原，030001太原，中心实验室 |
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| 摘 要： | 观察橙皮苷对链脲佐菌素导致的糖尿病大鼠肾脏功能和形态的影响,并与氨基胍进行比较。结果表明:（1）两治疗组大鼠尿蛋白排泄量显著低于对照组P<0.05）;（2）两治疗组肾组织AGEs和LPO含量显著低于对照组（P<0.01,P<0.05）:（3）治疗组肾小球系膜增生和基底膜增厚明显减轻。提示橙皮苷在抑制蛋白非酶糖基化、预防糖尿病肾脏并发症方面具有与氨基胍相似的作用。
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| 关 键 词： | 糖尿病.实验性 肾脏病变 橙皮苷 |
EFFECT OF HESPRIDIN AND AMINOGUANIDINE ON KIDNEY FUNCTION AND MORPHOLOGY IN STZ-INDUCED DIABETIC RATS |
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| Wang Xin-jia,He Guo-fen,Zhang Hui,et al.. EFFECT OF HESPRIDIN AND AMINOGUANIDINE ON KIDNEY FUNCTION AND MORPHOLOGY IN STZ-INDUCED DIABETIC RATS[J]. Chinese Journal of Endocrinology and Metabolism, 1996, 12(1): 34-36 |
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| Authors: | Wang Xin-jia He Guo-fen Zhang Hui et al. |
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| Affiliation: | Wang Xin-jia,He Guo-fen,Zhang Hui,et al. Department of Endocrinology,First Affiliated Hospital,Shan-xi Medical College,Taiyuan,030001 |
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| Abstract: | In this study, the effect of hespridin, a natural flavonoid, on renal function and morphology in streptozotocin induced diabetic rats was evaluated. The result was compared with that of aminoguanidine which can inhibit the formation of advanced glycosylation end products (AGEs) and can decreased diabetic complications in experimental diabetes. The results showed that excretion of urinary protein, and the content of AGEs and LPO decreased, while the mesangial expansion and basement membrane thickening were retarded in diabetic rats treated with hespridin. These indicate that hespridin plays the same protective role as aminoguanidine in inhibiting formation of AGEs, thus preventing the development of nephropathy in STZ induced diabetic rats. |
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| Keywords: | Diabetes experimental Nephropathy Hespridin |
| 本文献已被 CNKI 维普 等数据库收录！ |
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