| 汉族人MDR1 C3435T基因的多态性 |
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| 引用本文： | 岑宇翔,陆志诚,汪华侨,陈盛强. 汉族人MDR1 C3435T基因的多态性[J]. 解剖学研究, 2004, 26(1): 11-13 |
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| 作者姓名： | 岑宇翔 陆志诚 汪华侨 陈盛强 |
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| 作者单位： | 广州医学院第二附属医院,广州,510260;中山大学基础医学院 |
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| 摘 要： | 目的 检测汉族人MDR1C3435T基因的分布情况。方法 应用PCR技术对正常人外周血MDR1C3435T基因进行扩增以MboI进行限制性酶切图谱分析。结果 2 4 0例 (男 119例 ,女 12 1例 )汉族人MDR1C3435T基因中 ,表现型T/T频率是 18 75 % ,表现型T/C是 4 4 17% ,表现型C/C是 37 0 8%。MDR1C3435T基因T频率是 0 4 0 83,基因C频率是0 5 916。结论 汉族人MDR1C3435T基因的分布有自己的特点 ,为研究MDR1C3435T基因在某些疾病中的作用提供了可靠的基础资料。
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| 关 键 词： | MDR1 C3435T 汉族人 基因多态性 |
| 修稿时间： | 2003-12-05 |
Detection of MDR1 (C3435T) polymorphism in the Hans of Chinese |
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| Shen Yuxian,Lu Zhichen,Wang Huaqiao,Chen Shengqiang.Research Institute of Neuroscience Guangzhou Medical College,Guangzhou China. Detection of MDR1 (C3435T) polymorphism in the Hans of Chinese[J]. Anatomy Research, 2004, 26(1): 11-13 |
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| Authors: | Shen Yuxian Lu Zhichen Wang Huaqiao Chen Shengqiang.Research Institute of Neuroscience Guangzhou Medical College Guangzhou China |
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| Affiliation: | Shen Yuxian,Lu Zhichen,Wang Huaqiao,Chen Shengqiang.Research Institute of Neuroscience Guangzhou Medical College,Guangzhou 510260 China |
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| Abstract: | Objective To identify the distribution feature of MDR1(C3435T) gene in Hans in Guangdong province. Method MDR1(C3435T) gene from normal individuals were amplified with PCR and their restricted enzyme digested maps analysis were done with Mbo I. Results Genotypefrequency: MDR1(C3435T) *T/*T 0.1875;*T/*C 0.4417;*C/*C0.3708; MDR1(C3435T)genefrequenc:MDR1(C3435T)*T0.4083;MDR1(C3435T)*C 0.5917.Conclusion The MDR1(C3435T) genes distrbution in the Hans in Guangdong province is different from those in other areas. |
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| Keywords: | MDR1(C3435T) Hans population Genetic polymorphism |
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