血清铁蛋白水平与骨密度的相关性研究

目的分析绝经后女性及50岁以上男性不同骨量人群血清铁蛋白的差异，探讨血清铁蛋白水平与骨密度的相关性。 方法选择2018年9月至2019年2月期间于河北医科大学第三医院就诊，接受双能X线骨密度测量仪（DEXA）检测骨密度（BMD）的绝经后女性（131例）及50岁以上男性（65例）患者（共196例），根据BMD分为骨量正常组（46例）、骨量减少组（68例）和骨质疏松组（82例）。收集上述患者的临床资料，检测相关生化指标，并测定血清铁蛋白水平，评估血清铁蛋白与骨密度的相关性。 结果（1）与骨量正常组[99.50（91.55，128.51）ng/ml]和骨量减少组[103.36（93.26，113.46）ng/ml]相比，骨质疏松组血清铁蛋白水平明显增高[（174.25（160.85，210.42）ng/ml）（χ²=100.573，P=0.000）。（2）血清铁蛋白水平与髋部、腰椎骨密度均呈负相关，（髋部r=-0.487，P<0.05；腰椎r=-0.531，P<0.05）。（3）体重为骨质疏松症的保护因素（r=0.049，P<0.05），血清铁蛋白为骨质疏松症的危险因素（r=-0.018，P<0.05）。 结论血清铁蛋白水平增高是骨质疏松症的危险因素，在骨质疏松症的发生中可能起重要作用。

The relationship between Serum ferritin and Osteoporosis

Objective To analyze the difference of serum ferritin among postmenopausal women and men older than 50 years with different bone mass,and to explore the correlation between serum ferritin level and bone mineral density(BMD).Methods Postmenopausal women(n=131)and men(n=65)older than 50 years who received DEXA from September 2018 to February 2019 were enrolled in this study.They were divided into normal(46 cases),osteopenia(68 cases)and osteoporosis(82 cases)groups.Clinical data and biochemical parameters were collected.The level of serum ferritin was detected,and its correlation with BMDwas also determined.Results 1.Compared with normal and osteopenia group,serum ferritin level was significantly increased in osteoporosis group[174.25(160.85,210.42)ng/ml vs.99.50(91.55,128.51)ng/ml and 103.36(93.26,113.46)ng/ml,c2=100.573,P<0.05].2.The level of serum ferritin was negatively correlated with BMD in hip and lumbar spine(hip r=-0.487,P<0.05;lumbar vertebrae r=-0.531,P<0.05).3.Multivariate binary logistic regression analysis showed that body weight was the protective factor for osteoporosis(r=0.049,P<0.05),and serum ferritin was the risk factor for osteoporosis(r=-0.018,P<0.05).Conclusion Serum ferritin plays an important role in the prevalence of osteoporosis,which may be a risk factor for osteoporosis.