人工麝香对退变颈椎间盘炎症抑制作用的实验研究

实验选用１５只新西兰兔，分为３组，每组５只，分别为颈椎病模型组，对照组及和颈椎病模型加人工麝香饲养组。在造模后８月时处死动物。颈椎病模型加人工麝香饲养组动物在处死前喂以人工麝香２周。取动物颈椎间盘组织，用生化方法测定其中组织胺、５－羟色胺、ＰＧＥ２及６－酮－ＰＧＦ１ａ水平，结果表明：（１）颈椎病模型动物颈椎间盘中四种炎症介质水平明显高于其正常对照组动物的水平。（２）人工麝香对退变颈椎间盘中的四种炎症介质水平具有明显降低作用。

The Experimental Study of the Inhibitory Effect of Synthetic Moschus on Inflammation of Degenerative Cervical Disc

In experiment,15 White NewZealand rabbits were used and divided into three groups:control group,model group of cervical spondylosis,and model group with Synthetic Moschus of cervical spondylosis.Model of cervical spondylosis was established by method that we reported previously.Animals were killed eight months after operation.The model group with Synthetic Moschus were fed with Synthetic Moschus two weeks before being killed.The levels of histamine,5-OH-tryptamine,PGE2 and 6-Keto-PGF 1a were assayed with biochemical methods in all animal disc samples.The results were concluded as follows:(1) The levels of four inflammatory mediators from the cervical discs of model groups were overtly higher than that of control group.(2)Synthetic Moschus could obviously decrease levels of four inflammatory mediators of degenerative discs.