Bone Mineral Density and Androgen Levels in Elderly Males |
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Authors: | A Rapado F Hawkins L Sobrinho M Díaz-Curiel A Galvao-Telles S Arver J Melo Gomes N Mazer J Garcia e Costa C Horcajada E López-Gavilanes M Mascarenhas K Papapietro Ma B López Álvarez Ma C Pereira G Martinez I Valverde J J García J J Carballal I García |
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Institution: | (1) Clínica de Na Sra de la Concepción, Fundación Jiménez Díaz, Madrid, Spain, ES;(2) Hospital ``12 de Octubre', Madrid, Spain, ES;(3) Portuguese Cancer Institute, Lisbon, Portugal, PT;(4) Hospital de Santa María, Lisbon, Portugal, PT;(5) Karolinska Hospital, Stockholm, Sweden, SE;(6) Hospital Militar Principal, Lisbon, Portugal, PT;(7) Theratech Inc., Salt Lake City, Utah, USA, US;(8) CIBEST, Madrid, Spain, ES;(9) CEPA, S.L., Madrid, Spain, ES;(10) Neomed/Bioty, Lda, Lisbon, Portugal, PT |
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Abstract: | To clarify the relationship of sex male hormones and bone in men, we studied in 140 healthy elderly men (aged 55–90 years)
the relation between serum levels of androgens and related sex hormones, bone mineral density (BMD) at different sites, and
other parameters related to bone metabolism. Our results show a slight decrease of serum-free testosterone with age, with
an increase of follicle stimulating hormone (FSH) and luteinizing hormone (LH) in a third of the elderly subjects studied.
BMD decreased significantly with age in all regions studied, except in the lumbar spine. We found a positive correlation between
body mass index (BMI) and BMD at the lumbar spine and femoral neck (P < 0.001). No relationship was found (uni- and multivariate regression analysis) between serum androgens or sex hormone-binding
globulin (SHBG) and BMD. We found a positive correlation of vitamin D binding protein (DBP) and osteocalcin with lumbar spine
BMD and with BMI, DBP, IGF-1, and PTH with femoral neck BMD. In conclusion, there is a slight decline in free testosterone
and BMD in the healthy elderly males. However, sex male hormones are not correlated to the decrease in hip BMD. Other age-related
factors must be associated with bone loss in elderly males.
Received: 29 April 1997 / Accepted: 9 November 1997 |
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Keywords: | : Free testosterone — Androgens — Bone mineral density — Osteoporosis |
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