| 全胃肠外营养对肝硬化大鼠肝功能及脂代谢的影响 |
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| 引用本文： | 罗时敏,梁力建.全胃肠外营养对肝硬化大鼠肝功能及脂代谢的影响[J].肝胆外科杂志,2004,12(1):66-67. |
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| 作者姓名： | 罗时敏 梁力建 |
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| 作者单位： | 中山大学附属第一医院肝胆外科,广州,510080;中山大学附属第一医院肝胆外科,广州,510080 |
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| 摘 要： | 目的 观察全胃肠外营养对肝硬化大鼠肝功能及脂代谢的影响。方法 1 3只肝硬化大鼠随机分成 2组 ,肝硬化对照组 6只 ,肝硬化 TPN组 7只。观察大鼠生存情况 ,大鼠肝功能、血脂水平和肝脂含量的变化。结果 除 TPN组有一只大鼠因输液过快、肺水肿死亡外 ,其余大鼠均成活。与对照组比较 ,TPN组血清 TBIL、AST和 AL T无显著性差异 (P>0 .0 5 ) ,AL B明显降低 (P<0 .0 5 ) ,血清 TG水平明显升高 (P<0 .0 5 ) ,肝 TG、CHO含量明显升高 (P<0 .0 5 )。结论 硬化肝 TPN时要注意观察肝功能和脂代谢的变化
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| 关 键 词： | 全胃肠外营养 肝硬化 肝功能 脂代谢 |
| 文章编号： | 1006-4761(2004)01-0066-02 |
| 修稿时间： | 2002年11月30 |
EFFECTS OF TOTAL PARENTERAL ON LIVER FUNCTION AND LIPID METABOLISM IN THE CIRRHOTIC RATS |
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| LUO Shi min,LIANG Li jian.EFFECTS OF TOTAL PARENTERAL ON LIVER FUNCTION AND LIPID METABOLISM IN THE CIRRHOTIC RATS[J].Journal of Hepatobiliary Surgery,2004,12(1):66-67. |
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| Authors: | LUO Shi min LIANG Li jian |
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| Institution: | LUO Shi min,LIANG Li jian.Department of hepatobiliary surgery,the first affiliated hospital of Sun Yat Sen University,Guangzhou 510080,China) |
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| Abstract: | Objective To investigate the effects of total parenteral nutrition (TPN) on liver function and lipid metabolism in the cirrhotic rats.Methods Thirteen cirrhotic rats were divided into two groups randomly: control group (n=6) and TPN group (n=7).Survival rate,Liver function,serum lipid and liver were observed.Result All animals survived but one rat died of pneumonedema in TPN group.Compared with control group,serum TBIL,AST and ALT had not significantly changes ( P >0.05),ALB was decreased significantly ( P <0.05),serum TG was increased significantly ( P >0.05),Liver TG and CHO were increased significantly ( P <0.05).Conclusion The changes of liver function and lipid metabolism must be observed when adminstration TPN on cirrhotic liver. |
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| Keywords: | Total parenteral nutrition Cirrhosis Liver function Lipid metabolism |
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