Effect of cyproterone acetate on testis and accessory sex organs of male rat

A significant reduction in testis, epididymis, seminal vesicles, prostate, and adrenal weight of adult rats was observed after CA treatment (10 mg/animal/day) for 13, 26 and 39 days. Biochemical assay on the epididymis showed a fall in the activities of acid and alkaline phosphatase. A significant fall in citric acid content of seminal vesicle and prostate in experimental animals was noted after CA treatment. Histoarchitecture of accessory sex organs was severely impaired.