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| EGFR在胰腺癌组织芯片中的表达及其临床意义的研究 | |
| 引用本文： | 唐来,刘煦禾,华惠英,杜媛,李峰.EGFR在胰腺癌组织芯片中的表达及其临床意义的研究[J].海南医学院学报,2011,17(7):890-893,896. |
| 作者姓名： | 唐来 刘煦禾 华惠英 杜媛 李峰 |
| 作者单位： | 1. 苏州工业园区唯亭医院消化内科,江苏苏州,215121 2. 苏州工业园区唯亭医院普外科,江苏苏州,215121 3. 苏州工业园区娄葑医院护理部,江苏苏州,215006 4. 苏州大学第二附属医院病理科,江苏苏州,215004 |
| 基金项目： | 海南医学院科研基金学报项目 |
| 摘 要： | 目的:探讨表皮生长因子受体EGFR蛋白在胰腺癌组织中的表达及其与胰腺癌临床病理参数和生物学预后的相关性及意义.方法:将88例无术前放化疗史的胰腺癌手术标本和11例非肿瘤性胰腺组织制成组织芯片,采用免疫组化法检测EGFR蛋白的表达情况,并对随访2个月～6年的54例病例作生存分析.结果:获得1个胰腺癌组织芯片蜡块,含99个... |
| 关 键 词： | 胰腺癌 EGFR 组织芯片 免疫组织化学 |
Expression of EGFR in pancreatic carcinoma |
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| TANG Lai,LIU Xu-he,HUA Hui-ying,DU Yuan,LI Feng.Expression of EGFR in pancreatic carcinoma[J].Journal of Hainan Medical College,2011,17(7):890-893,896. | |
| Authors: | TANG Lai LIU Xu-he HUA Hui-ying DU Yuan LI Feng |
| Institution: | 1.Department of Gastroenterology,Weiting Hospital of Suzhou Industrial Area,Suzhou 215121,China;2.Department of General Surgery,Weiting Hospital of Suzhou Industrial Area;3.Department of Nursing,Loufeng Hospital of Suzhou Industrial Area,Suzhou 215006,China;4.Department of Pathology,the Second Hospital Affiliated to Soochow,Suzhou 215004,China) |
| Abstract: | Objective： To investigate the expression of EGFR in pancreatic adenocarcinoma,and to explore its relationship with clinicopathologic parameters and the effect on prognosis.Methods： Immunohistochemical method was used to examine the expression of EGFR protein in tissues from 88 cases of pancreatic carcinoma without history of chemo-radiation therapy and from 11 cases without tumor.All 54 cases were followed-up from 2 months to 6 years.Results： A paraffin-embedded pancreatic carcinoma tissue microarray was successfully constructed,including 99 tissue spots.Positive expression rate of EGFR in tumors was 59.1%（52/88）.In contrast,no overexpression of EGFR in non tumorous pancreatic tissues was detected（P〈0.01）.The expression of EGFR was significantly correlated with size of tumor and TNM stage（P〈0.05）.Cox stepwise proportional hazards analysis showed that EGFR expression was associated with prognosis of pancreatic adenocarcinoma.Conclusions： The expression of EGFR is associated with clinicopathologic parameters and prognosis of pancreatic carcinoma.It would become a independent index for tumor prognosis. |
| Keywords: | Pancreatic carcinoma EGFR Tissue microarray Immunohistochemistry |
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