帕罗西汀联合心理干预治疗脑卒中后抑郁的临床研究

目的 观察帕罗西汀联合心理干预治疗脑卒中后抑郁(Post-stroke depression,PSD)的临床疗效.方法 随机将脑卒中后抑郁患者分为研究组和对照组,每组各30例,两组均给予帕罗西汀20～40 mg每天早晨服用；研究组同时予以每周3次心理干预.治疗前和治疗后分别用汉密尔顿抑郁量表(Hamilton depr...

Effect of Paroxetine combined with psychological intervention in the treatment of patients with post-stroke depression

Objective To observe the effect of Paroxetine combined with psychological intervention for treating post-stroke depression. Methods Sixty patients with post-stroke depression (PSD) were divided into the study group and the control group, each with 30 cases. Patients in the two groups were treated with 20~40 mg paroxetine every morning. Those in the study group were additionally treated with psychological intervention three times a week. The therapeutic efficacy was evaluated through Hamilton depression scale (HAMD) and Stroke patients with neurological impairment score standard (1995) before treatment and after treatment. Results Eight weeks after treatment, the total effective rates of the treatment of depression and neurological impairment were 86.67% and 76.67% in the study group which were significantly higher than those in the control group (53.33% and 43.33%, respectively). Conclusion Paroxetine combined with psychological intervention can significantly improve anti-depression and recovery degree of neurological impairment, which results in better therapeutic efficacy than paroxetine alone.