CA-125对上皮性卵巢癌患者预后的评估

目的：评价初诊上皮性卵巢癌患者血清CA-125水平与其预后的关系.方法：回顾性分析145例初诊上皮性卵巢癌患者血清CA-125水平与FIGO分期、肿瘤细胞分化程度的关系.采用Kaplan-Meier生存曲线分析初诊患者血清CA-125水平与其远期预后的关系,并利用Cox风险比例模型分析血清CA-125水平与患者远期预后的独立相关性.结果：初诊卵巢癌患者血清CA-125水平随着FIGO分期的增加而逐渐增高,随着肿瘤细胞分化程度的增加而逐渐降低.血清CA-125≤194.10kU/L的患者,其远期预后优于血清CA-125＞ 194.10kU/L.Cox风险比例模型表明,在校正了年龄,FIGO分期,肿瘤细胞分化程度等因素后,血清CA-125水平增高（＞194.10kU/L）与患者远期预后的风险比为1.750 （95％ CI：1.1053～2.773）.结论：血清CA-125水平是上皮性卵巢癌患者预后的独立危险因子.

The prognosis value of initial serum CA125 for long-term mortality in epithelial ovarian cancer patients

Objective：To evaluate the prognosis value of initial serum CA-125 level in epithelial ovarian cancer patients. Methods ：The association between initial serum CA-125 level with FIGO grade, as well as tumor cell differentiation grade, was retrospectively analyzed in 145 epithelial ovarian cancer patients. Kaplan-Meier survive curve and Cox proportional hazard model were used to assess the prognosis value of initial serum CA-125 level in epithelial ovarian cancer patients. Results：The serum CA-125 level in epithelial ovarian cancer patients was increased as the progress of FIGO grade, but decreased as the progress of tumor cell differentiation grade. Lower serum CA-125 level （≤194.10kU/L） was associated with higher survive rate than that of higher serum CA-125 level. The serum CA-125 level was associated with long term survival rate after adjusted for age, FIGO grades,tumor cell differentiation grade etc. Conclusion： The initial serum CA-125 level was an independent prognosis factor for epithelial ovarian cancer patients.