冬胃颗粒三联疗法治疗寒凝血瘀型消化性溃疡的临床研究

目的：观察冬胃颗粒联合奥美拉唑、铋剂、三联治疗寒凝血瘀型消化性溃疡的疗效与安全性。方法：66例寒凝血瘀型消化性溃疡患者随机分为两组，实验组（n ＝33），给予冬胃颗粒8g 3次/日＋奥美拉唑40mg 1次/日＋铋剂220mg 3次/日；对照组（n ＝33），给予阿莫西林500mg 3次/日＋甲硝唑0．2 g 3次/日＋奥美拉唑40mg 3次/日＋铋剂220mg 3次/日。以上药物除抗生素服用2周停药，其他药物服至6周结束，第7周复查胃镜和14 C -尿素呼气实验。结果：在临床症状方面，三联使用“冬胃颗粒”在腹痛指标的评价上优于对照组（P ＜0．01），主要差异表现在治疗后第2周；在泛酸、嗳气、纳差三项指标两组未见显著差异（P ＞0．05）。虽然实验组 HP 根除率（58．8％）略低于对照组（71．5％）（P ＜0．05），但其溃疡愈合率（86．6％）与 S2期获得率（61．5％）与对照组比较（85．8％、60．8％），差异无统计学意义（P ＞0．05）。两组均未见明显副作用。结论：冬胃颗粒三联疗法可有效治疗寒凝血瘀型消化性溃疡，腹痛症状的缓解较传统三联疗法快且彻底，且无明显副作用，溃疡治愈率与传统三联疗法相似。

Dongwei Granule Based Triple Therapy for PU with Cold Obstruction Causing Blood Stasis

Objective： To evaluate the clinical efficacy and safeness of Dongwei granule based triple therapy on peptic ul -cer （PU） with cold obstruction causing blood stasis .Method： 66 patients of PU with cold obstruction causing blood sta -sis were selected for random parallel controlled trial .33 cases in the study group were treated with Dongwei granule based triple therapy, Dongwei granule 8g tid plus omeprazole once daily and colloidal Bismuth Pectin 220mg tid, while other 33 patients in the control group were given omeprazole once daily plus colloidal Bismuth Pectin 220mg tid plus Amoxicillin 500mg tid plus metronidazole 40mg tid.The antibiotics above were taken for two weeks , and others were for six weeks.Gastroscopy and 14 C -UBT were rechecked on the seventh week .Results：The evaluation of curative effect of Dongwei granule based triple therapy in abdominal pain gained an advantage over that in the control group after the sec -ond week （P ＆lt;0.01）; there was no statistical significance of curative effect between two groups in belching , anorexia and water brash （P ＆gt;0.05）;the eradication rate of HP in the study group（58.8%） was a little bit lower than that in the control group（71.5%）（P ＆lt;0.05）,nevertheless, the healing rate of the ulcer and the stage S2 pick -up rate were the same in the two groups （P ＆gt;0.05）; no obvious side effects were found .Conclusion： Dongwei granule based triple therapy could cure PU with cold obstruction causing blood stasis , and quickly relieve the abdominal pain and the recov -ery rate was similar to traditional trigeminy treatment .