扶正解毒法干预宫颈 HR-HPV感染的临床研究

目的：观察扶正解毒法干预宫颈高危型人乳头瘤病毒（简称HR-HPV）感染的临床疗效及患者体内血清IL-6的变化，探讨扶正解毒法干预宫颈HR-HPV感染的临床价值及作用机制。方法：将宫颈高危型人乳头状病毒感染患者120例随机分成中药联合组（口服扶正解毒汤联合外用清毒散），单纯中药上药组和西药上药组（α-干扰素），比较三组治疗前后症状、体征积分，HR-HPV病毒载量及血清IL-6的变化。结果：治疗后中药联合组分别与对照组中药上药组、西药上药组比较，症状、体征积分下降更明显，说明中药联合组能明显改善患者症状、体征评分，且优于对照组；治疗后中药联合组与对照组中药上药组、西药上药组比较，病毒载量下降更快，差异有统计学意义（P＜0．05）。说明中药联合组能显著降低HPV载量值，且明显优于对照组中药上药组和西药上药组；三组治疗前血清IL-6差异无统计学意义（P＞0．05），治疗后中药联合组血清IL-6下降明显，而中药上药组和西药上药组无明显变化，差异有统计学意义（P＜0．05）。结论：中药扶正解毒法能有效治疗宫颈高危型人乳头状病毒感染，提高机体免疫功能，阻断宫颈疾病进展。

Clinical Study of Fuzheng Jiedu Therapy in the Treatment of Cervical High-risk Human Papilloma Virus Infection

Objective： To study Fuzheng Jiedu therapy in the treatment of cervical high -risk human papilloma virus （HR-HPV） infection and changes of serum IL -6.Discuss the clinical value and action mechanism of Fuzheng Jiedu therapy in the treatment of cervical HR -HPV.Methods：According to the random method ,120 cases of cervical HR-HPV infection patients were divided into three groups ： Chinese Medication combination group （ taking orally with Fuzheng Jiedu soup and external use of Xiaodu powder ） , Chinese medication external use group , western medication （interferon-alpha） external use group.Change of the symptom,the score of symptom,the viral loads of HR-HPV,the serum IL-6 were compared among three groups .Results： After treatment , the Chinese medication combination group had an obviously better effect than other two control groups ,the Chinese medication combination group ’ s viral loads of HR-HPV declined faster than those in other two control goups , and there was a significant difference among three groups （ P〈0 .05 ） .Before treatment , the serum IL-6 value of the three groups had no significantly statistical difference （P〉0.05）.After treatment, the Chinese medication combination group’s serum IL-6 value decreased significantly, the serum IL-6 value of other two control groups had no obvious change ,and there was a significant difference among three groups （ P〈0 .05 ） .Conclusion：Fuzheng Jiedu therapy has an obvious effect in the treatment of cervical high -risk human papilloma virus（HR-HPV）,and can improve the immune function of organism and block the progress of the cervical virus.