益气活血化瘀法联合化疗治疗晚期乳腺癌的临床观察

目的：观察益气活血化瘀方配合化疗治疗晚期乳腺癌的临床疗效。方法：将54例复发转移性晚期乳腺癌患者随机分为两组，治疗组27例，采用自拟益气活血化瘀方配合FAC方案治疗，对照组27例，单纯应用FAC方案治疗。两组均于4周期化疗后评定疗效，分别观察近期疗效、生活质量、不良反应发生情况及免疫学指标、肿瘤标志物等变化。结果：入组54例病例，无脱落病例，总有效率治疗组70．37％，对照组40．74％，两组比较差异有统计学意义（ P＜0．05）；生存质量改善情况，治疗组和对照组KPS评分提高稳定率分别为92．59％，66．67％，两组比较，差异显著（P＜0．05）；治疗组治疗过程中白细胞、血小板、血红蛋白下降和恶心呕吐、神经毒性及心电图改变的发生均明显低于对照组，两组比较差异具有统计学意义（P＜0．05）；免疫学指标变化，治疗组CD3^＋，CD4^＋及NK细胞活性明显升高，CD8＋明显降低，对照组患者治疗后CD3^＋、CD4^＋细胞活性明显降低，差异具有统计学意义（ P＜0．05）；两组治疗后CEA、CA153与本组治疗前及两组治疗后比较差异均有统计学意义（ P＜0．05）。结论：益气活血化瘀法联合化疗治疗晚期乳腺癌能控制病情发展，提高患者生活质量，减轻化疗的不良反应，提高细胞免疫功能，具有较好的疗效。

Clinical Research on Treatment of Advanced Breast Cancer Based on Yiqi Huoxue Huayu Method Combined with Chemotherapy

Objective：To observe the clinical effect for Yiqi Huoxue Huayu method combined with chemotherapy on ad -vanced breast cancer .Methods：Select 54 patients with advanced breast cancer and they were randomly divided into two groups .27 patients in treatment group were administered with “FAC chemotherapy combined with Chinese herbs”;27 patients in control group were with “FAC chemotherapy”.Observe the changes with tumor size , KPS, toxic side effects ,immunology indexes and the values of CEA and CA 153 between groups after four cycles of chemotherapy .Results：The effective rate in the treatment group was 70.37%;the control group was 40.74%, and there was a significant difference （ P〈0 .05 ） .The KPS score increase stable rate of treatment group and the control group were respectively 92 .59%and 66.67%, and there was a significant difference （P〈0.05）.In treatment group, the incidences of the classes of leuko-cyte, platelet and hemoglobin degression , nausea and vomiting , neurotoxicity and ECG changes were significantly lower than those of the control group （P〈0.05）.After treatment,the immune indexes of CD3 ＋,CD4 ＋and NK cells were sig-nificantly increased and the immune indexes of CD8^＋was decreased in treatment group, and in control group,the im-mune indexes of CD3^ ＋, CD4^ ＋ were significantly decreased .By comparison, those differences were significant （ P 〈0.05 ） .There were also differences between two groups in CEA and CA 15-3 after treatment （ P〈0 .05 ） .Conclusion：Traditional Chinese medicine method with Yiqi Huoxue Huayu method can control the progress of advanced breast canc -er, raise life quality, alleviate the side effect of chemotherapy and improve immune function .