联合增强MR与DWI评估星形细胞瘤生物学特性的应用研究

目的:通过分析星形细胞瘤强化及DWI成像特点与临床病理指标,探讨MR评估星形细胞瘤生物学特性的价值。方法:应用GE Signa EXCITE HD 3.0T超导型磁共振扫描仪及头部八通道线圈,对67例星形细胞瘤术前进行增强MR和DWI成像检查,利用Functiontool软件对获得图像进行处理,记录肿瘤组织强化率和ADC值。根据术后HE病理图片进行细胞密度分析和WHO分级。对强化率、ADC值、细胞密度及WHO分级进行统计分析。结果:高级别星形细胞瘤强化率为(66±12)%,高于低级别星形细胞瘤强化率(36±8)%,P=0.00。高级别星形细胞瘤的ADC为(1.11±0.10)×10-3 mm2/s,低级别星形细胞瘤的ADC为(1.55±0.31)×10-3 mm2/s,P=0.00;高级别星形细胞瘤的细胞密度为(11.85±4.36)%,大于低级别星形细胞瘤的细胞密度(4.74±2.96)%,P=0.00;肿瘤的ADC值与细胞密度、WHO分级和强化率呈负相关,P值分别为0.00、0.00和0.01;肿瘤强化率与WHO分级正相关,P=0.04。结论:增强MR和DWI能从不同角度反映星形细胞瘤生物学特性,肿瘤强化率与ADC相关性从影像学角度反映出组织灌注水平与微观结构的内在关系。

Application study of combining CE-MR with DWI in evaluating the biological behavior of astrocytoma

OBJECTIVE: To analyze the value of combining contrast-enhance MR(CE-MR) with DWI in evaluating the biological behavior of astrocytoma.METHODS: The clinic and pathologic information of 67 patients with histologically proven astrocytoma were studied.CE-MR and diffusion weighted imaging(DWI) were carried out on a GE Signa EXCITE HD 3.0T MR.All of the data was transferred to GE Advanced Workstation 4.2.The enhancement rate and ADC values of astrocytoma were recorded.The WHO grade and cellular density of astrocy...