Efficacy of ginkgolic acids against Cryptosporidium andersoni in cell culture |
| |
| Authors: | Wu Liang Jiang Xu-gan Shen Yu-juan Lu Zhao-xi Tu Guo-hua Fu Xing-li Chen Sheng-xia Cao Jian-ping |
| |
| Affiliation: | (1) School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, 212013, People’s Republic of China;(2) National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Laboratory of Parasite and Vector Biology, MOH, Shanghai, People’s Republic of China;(3) WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai, 200025, People’s Republic of China; |
| |
| Abstract: | Cryptosporidium is a worldwide waterborne parasite and the treatment is a severe problem in immunocompromised patients. In this study, we used the in vitro culture system to evaluate the anti-Cryptosporidium activity of ginkgolic acids (GAs), nitazoxanide (NTZ), garlicin (GAR), and artemether (ART). The growth of Cryptosporidium andersoni in HCT-8 cells was determined by real-time PCR assay. When exposed to 5.00 μg/ml GAs or 10.00 μg/ml NTZ for 48 h, the number of C. andersoni in cultures was on a very low lever, but the number of parasites did not significantly decrease when exposed to GAR and ART. Our results indicate that GAs could be a potential drug for the treatment of cryptosporidiosis. |
| |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
