| 喉鳞癌组织Snail mRNA与E-cadherin mRNA表达及其临床意义的探讨 |
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| 引用本文： | 张华东,熊正文,黄勇,李宏伟,苏红,李伟,寻凤华.喉鳞癌组织Snail mRNA与E-cadherin mRNA表达及其临床意义的探讨[J].中华肿瘤防治杂志,2011,18(18):1458-1461. |
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| 作者姓名： | 张华东 熊正文 黄勇 李宏伟 苏红 李伟 寻凤华 |
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| 作者单位： | 中国人民解放军第二五一医院病理科(北京军区肿瘤病理技术研究诊疗中心),河北张家口,075000 |
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| 摘 要： | 目的:观察Snail mRNA与E-cad-herin mRNA在喉鳞癌组织中的表达及其与临床病理特征的关系。方法:应用原位分子杂交方法,分别检测Snail mRNA与E-cadherin mRNA在60例喉鳞癌、30例不典型增生和20例慢性炎症组织中的表达。结果:Snail mRNA在喉鳞癌中的表达高于不典型增生和慢性炎症组织中的表达,而E-cadherin mRNA在喉鳞癌中的表达低于不典型增生和慢性炎症组织中的表达,差异均有统计学意义,P值均<0.05;Snail mRNA、E-cadherin mRNA与喉鳞癌甲状软骨累及淋巴结转移、TNM分期、T分期、临床分型、病理分级有关(P值均<0.05),而两者均与性别、年龄、肿瘤大小无关,P值均>0.05;喉鳞癌Snail mRNA和E-cadherin mRNA的表达呈明显负相关,r=-0.504,P<0.05。结论:E-cadherin mRNA低表达与Snail mRNA高表达可能是喉黏膜恶性转变以及喉鳞癌发生浸润转移的重要生物学标志,联合检测E-cadherin mRNA和Snail mRNA对预测喉鳞癌浸润转移有重要意义。
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| 关 键 词： | Snail E-cadherin 喉肿瘤 原位分子杂交 |
Expression and clinical significance of Snail mRNA and E-cadherin mRNA in laryngeal squamous cell carcinoma |
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| ZHANG Hua-dong,XIONG Zheng-wen,HUANG Yong,LI Hong-wei,SU Hong,LI Wei,XUN Feng-hua.Expression and clinical significance of Snail mRNA and E-cadherin mRNA in laryngeal squamous cell carcinoma[J].Chinese Journal of Cancer Prevention and Treatment,2011,18(18):1458-1461. |
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| Authors: | ZHANG Hua-dong XIONG Zheng-wen HUANG Yong LI Hong-wei SU Hong LI Wei XUN Feng-hua |
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| Institution: | ZHANG Hua-dong,XIONG Zheng-wen,HUANG Yong,LI Hong-wei,SU Hong,LI Wei,XUN Feng-hua Department of Pathology,No.251 Hospital of PLA(Beijing Military Treatment and Diagnosis of Pathology Technology Research Center of Tumors),Zhangjiakou 075000,P.R.China |
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| Abstract: | OBJECTIVE: To investigate the expression of Snail mRNA and E-cadherin mRNA in laryngeal squamous cell carcinoma with expression and clinico-pathological features.METHODS: The expression of Snail mRNA and E-cadherin mRNA was detected by using in situ hybridization(ISH) in 60 cases of laryngeal squamous cell carcinoma,30 cases laryngeal atypical and 20 cases chronic inflammation of the larynx.RESULTS: The expression of Snail mRNA in laryngeal squamous cell carcinoma was higher than that in the laryngeal atypi... |
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| Keywords: | Snail E-cadherin laryngeal neoplasms in situ hybridization |
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