| 乳腺癌新辅助化疗MR灌注成像与微血管密度的相关性研究 |
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| 引用本文： | 张蓓,魏冉,胡文娟,王兰云,黄彩虹. 乳腺癌新辅助化疗MR灌注成像与微血管密度的相关性研究[J]. 中华肿瘤防治杂志, 2011, 18(17): 1387-1391 |
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| 作者姓名： | 张蓓 魏冉 胡文娟 王兰云 黄彩虹 |
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| 作者单位： | 1. 上海市瑞金医院集团闵行区中心医院放射科,上海 201100;上海交通大学医学院附属瑞金医院放射科,上海 200025
2. 上海市瑞金医院集团闵行区中心医院放射科,上海,201100 |
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| 基金项目： | 上海市科学技术委员会自然科学基金资助项目(0911962800) |
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| 摘 要： | 目的:探讨乳腺癌新辅助化疗前后MR灌注成像与肿瘤微血管密度之间的相关性。方法:对20例乳腺癌患者在新辅助化疗前及化疗4个周期后手术前行磁共振灌注成像,并对化疗前穿刺及术后标本行免疫组织化学检测肿瘤的微血管密度,分析MR灌注成像最大信号丢失率与微血管密度在化疗前后的变化情况及其相关性。结果:按照实体肿瘤治疗反应评估标准(RECIST)指南,20例患者中,化疗有反应组16例(80%),无反应组4例(20%)。化疗后肿瘤灌注最大信号丢失率明显低于化疗前(P<0.05),有反应组最大信号丢失率明显下降(P<0.05),而无反应组最大信号丢失率未发生显著变化,P>0.05。化疗后肿瘤微血管密度明显降低(P<0.05),有反应组的CD34表达明显下降(P<0.05),而无反应组CD34表达的变化无统计学意义,P>0.05。化疗前后Ratio值变化率与CD34变化率之间存在正相关关系,r=0.703,P<0.05。结论:乳腺癌新辅助化疗前后磁共振灌注成像与微血管密度存在一定的相关性,可在一定程度上反映肿瘤的血管生成情况。
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| 关 键 词： | 乳腺肿瘤 新辅助化疗 磁共振 灌注成像 微血管密度 |
Correlation between MR perfusion-weighted imaging and micro-vessel density |
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| ZHANG Bei,WEI Ran,HU Wen-juan,WANG Lan-yun,HUANG Cai-hong. Correlation between MR perfusion-weighted imaging and micro-vessel density[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(17): 1387-1391 |
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| Authors: | ZHANG Bei WEI Ran HU Wen-juan WANG Lan-yun HUANG Cai-hong |
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| Affiliation: | ZHANG Bei1,2,WEI Ran1,HU Wen-juan1,WANG Lan-yun1,HUANG Cai-hong1 1.Department of Radiology,Central Hospital of Minhang District,Ruijin Hospital Group,Shanghai,201100,P.R.China 2.Department of Radiology,Ruijin Hospital,Medical College of Shanghai Jiaotong University,200025,P.R.China |
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| Abstract: | OBJECTIVE: To evaluate the correlation between the maximal signal intensity decrease ratio of perfusion-weighted(PWI) and micro-vessel density(MVD).METHODS: For 20 patients with breast cancer who receive neoadjuvant chemotherapy,MR PWI were performed pretreatment and after the fouth cycle of chemotherapy prior to surgery.The specimens of biopsy and surgery were collected.And the expression of CD34,which reflects the MVD of tumor,were detected by immunohistochemical stains.The maximal signal intensity decrea... |
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| Keywords: | breast neoplasms neoadjuvant chemotherapy MR PWI MVD |
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