Angiogenesis Markers Quantification in Breast Cancer and Their Correlation with Clinicopathological Prognostic Variables |
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Authors: | Jan Rykala Karolina Przybylowska Ireneusz Majsterek Grazyna Pasz-Walczak Andrzej Sygut Adam Dziki Julia Kruk-Jeromin |
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Institution: | (1) Department of Plastic, Reconstructive and Aesthetic Surgery, Barlicki Hospital, Medical University of Lodz, Kopcinskiego 22, 90–153 Lodz, Poland;(2) Department of Chemistry and Clinical Biochemistry, Medical University of Lodz, Hallera 1, 90–647 Lodz, Poland;(3) Department of Pathology, Medical University of Lodz, Paderewskiego 4, 93–509 Lodz, Poland;(4) Department of General and Colorectal Surgery, Medical University of Lodz, Hallera 1, 90–647 Lodz, Poland |
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Abstract: | Tumoural angiogenesis is essential for the growth and spread of breast cancer cells. Therefore the aim of this study was to
assess the diagnostic performance of angiogenesis markers in tumours and there reflecting levels in serum of breast cancer
patients. Angiogenin, Ang2, fibroblast growth factor basic, intercellular adhesion molecule (ICAM)-1, keratinocyte growth
factor (KGF), platelet-derived growth factor-BB, and VEGF-A were measured using a FASTQuant angiogenic growth factor multiplex
protein assay. We observed that breast cancer tumours exhibited high levels of PDGF-BB, bFGF and VEGF, and extremely high
levels of TIMP-1 and Ang-2, whereas in serum we found significantly higher levels of Ang-2, PDGF-BB, bFGF, ICAM-1 and VEGF
in patients with breast cancer compared to the benign breast diseases patients. Moreover, some of these angiogenesis markers
evaluated in tumour and serum of breast cancer patients exhibited association with standard clinical parameters, ER status
as well as MVD of tumours. Angiogenesis markers play important roles in tumour growth, invasion and metastasis. Our results
suggest that analysis of angiogenesis markers in tumour and serum of breast cancer patients using multiplex protein assay
can improve diagnosis and prognosis in this diseases. |
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