| 肿瘤标志对煤矿工人尘肺并发肺癌的鉴别诊断价值 |
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| 引用本文： | 万传远. 肿瘤标志对煤矿工人尘肺并发肺癌的鉴别诊断价值[J]. 中华肿瘤防治杂志, 2011, 18(17): 1367-1369 |
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| 作者姓名： | 万传远 |
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| 作者单位： | 淄博矿业集团有限责任公司双山医院检验科,山东淄博,255200 |
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| 摘 要： | 目的:探讨肿瘤标志在煤矿工人尘肺并发肺癌中的诊断价值。方法:应用电化学发光技术,检测98例尘肺并发肺癌患者、151例尘肺患者和252位健康煤矿工人血清细胞角蛋白21-1(Cyfra21-1)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)以及糖类抗原125(CA125)水平。结果:尘肺并发肺癌患者血清Cyfra21-1、NSE、CEA和CA125表达水平均显著高于患尘肺或健康煤矿工人,P<0.001。其中腺癌的CEA及CA125水平、鳞癌的Cyfra21-1表达水平以及小细胞癌的NSE表达水平比其他2种类型均高,且差异有统计学意义,P<0.001。以上单项肿瘤标志鉴别诊断尘肺和尘肺并发肺癌的准确性分别达到81.1%(202/249)、71.1%(177/249)、71.5%(178/249)和74.7%(186/249),联合检测准确性达87.6%(218/249)。结论:Cyfra21-1、NSE、CEA和CA125联合检测可用于煤矿工人尘肺并发肺癌的鉴别诊断,而且对判断肺癌的病理类型有辅助价值。
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| 关 键 词： | 肺肿瘤/诊断 尘肺/并发症 肿瘤标志,生物学 采煤 诊断,鉴别 |
Differential diagnosis of pneumoconiosis complicated with lung cancer by detection of tumor markers in coal miner |
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| WAN Chuan-yuan. Differential diagnosis of pneumoconiosis complicated with lung cancer by detection of tumor markers in coal miner[J]. Chinese Journal of Cancer Prevention and Treatment, 2011, 18(17): 1367-1369 |
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| Authors: | WAN Chuan-yuan |
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| Affiliation: | WAN Chuan-yuan Department of Clinical Laboratory,Shuangshan Hospital of Zibo Mining Group Co.LTD,Zibo 255200,P.R.China |
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| Abstract: | OBJECTIVE:To investigate the diagnostic value of serum tumor markers for pneumoconiosis complicated with lung cancer.METHODS: The serum tumor markers Cyfra21-1,NSE,CEA and CA125 were measured with electrochemistry iluminescence in 98 cases of pneumoconiosis complicated with lung cancer,151 cases of pneumoconiosis and 252 healthy coal miners.RESULTS:All the 4 tumor markers in lung cancer patients were significantly higher than that in pneumoconiosis and healthy controls(P<0.001).The levels of CEA and CA125 i... |
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| Keywords: | lung neoplasms/diagnosis pneumoconiosis/complications tumor marker biological coal mining diagnosis differential |
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