Presence of endothelial colony-forming cells is associated with reduced microvascular obstruction limiting infarct size and left ventricular remodelling in patients with acute myocardial infarction |
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Authors: | Meneveau Nicolas Deschaseaux Frédéric Séronde Marie-France Chopard Romain Schiele François Jehl Jérome Tiberghien Pierre Bassand Jean-Pierre Kantelip Jean-Pierre Davani Siamak |
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Institution: | (1) Service de Cardiologie, CHU Besan?on, IFR 133, EA 3920, University of Franche-Comt?, Besan?on, France;(2) INSERM U645, Etablissement Fran?ais du Sang Bourgogne Franche-Comt?, IFR133, University of Franche-Comt?, Besan?on, France;(3) Service de Radiologie, CHU Besan?on, University of Franche-Comt?, Besan?on, France;(4) Laboratoire de Pharmacologie Clinique et Toxicologie, CHU Besan?on, IFR 133, EA 3920, University of Franche-Comt?, Besan?on, France;(5) Department of Cardiology EA3920, University Hospital Jean Minjoz, 25000 Besan?on, France |
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Abstract: | Endothelial colony-forming cells (ECFCs) are known to increase after acute myocardial infarction (AMI). We examined whether
the presence of ECFCs is associated with preserved microvascular integrity in the myocardium at risk by reducing microvascular
obstruction (MVO). We enrolled 88 patients with a first ST elevation AMI. ECFC colonies and circulating progenitor cells were
characterized at admission. MVO was evaluated at 5 days and infarct size at 5 days and at 6-month follow-up by magnetic resonance
imaging. ECFC colonies were detected in 40 patients (ECFCpos patients). At 5 days, MVO was of greater magnitude in ECFCneg versus ECFCpos patients (7.7 ± 5.3 vs. 3.2 ± 5%, p = 0.0002). At 6 months, in ECFCpos patients, there was a greater reduction in infarct size (−32.4 ± 33 vs. −12.8 ± 24%; p = 0.003) and a significant improvement in left ventricular (LV) volumes and ejection fraction. Level of circulating CD34+/VEGF-R2+
cells was correlated with the number of ECFC colonies (r = 0.54, p < 0.001) and relative change in infarct size (r = 0.71, p < 0.0001). The results showed that the presence of ECFC colonies is associated with reduced MVO after AMI, leading to reduced
infarct size and less LV remodelling and can be considered a marker of preserved microvascular integrity in AMI patients. |
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