Oral granular cell tumours: a histological and immunocytochemical study |
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Authors: | Hazel K. Williams David M. Williams |
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Affiliation: | School of Dentistry, University of Birmingham. Birmingham and The London Hospital Medical College, London, UK |
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Abstract: | In a series of nine cases of intra-oral granular cell tumours (GCTs) an attempt was made, using both histochemical and immunocytochemical methods, to determine whether these tumours show Schwann-cell or neuroendocrine differentiation. Positive immunostaining with protein gene product 9.5 (PGP 9.5). neurone-specific enolase (NSE) and S-100. in contrast to predominantly negative immunostaining in 12 cases of neurilemmoma of the head and neck, and a similar pattern of staining with luxol fast blue to five known neuroendocrine tumours, strongly suggests that granular cell tumours may be neuroendocrine in nature. |
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Keywords: | granular cell tumour neuroendocrine tumours neurone-specific enolase protein gene product 9.5 |
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