| 抗风湿类中成药中添加糖皮质激素的检测 |
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| 引用本文： | 刘金艳,赵春杰,王超众. 抗风湿类中成药中添加糖皮质激素的检测[J]. 中国药品标准, 2008, 9(6): 424-427 |
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| 作者姓名： | 刘金艳 赵春杰 王超众 |
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| 作者单位： | 1. 沈阳药科大学,沈阳,111000
2. 齐齐哈尔市药品检验所,齐齐哈尔,161000 |
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| 摘 要： | 目的：建立检测抗风湿类中成药中可能添加5种糖皮质激素的定性、定量方法。方法：随机抽查市场上销售的十种抗风湿类中成药，采用TLC、HPLC法进行定性、定量分析。结果：硅胶G薄层板上，以二氯甲烷-乙醚-甲醇-水（385：60：15：2）为展开剂，喷以碱性四氮唑蓝试液显色，供试品与醋酸泼尼松对照品呈相同位置与颜色斑点，R，值为0．62。流动相：以乙腈-水为流动相，采用剃度洗脱，样品与对照品均实现基线分离。HPLC法对醋酸泼尼松定量分析，线性范围50—200mg·L^-1，R=0．9993。结论：本法简便、快速、分离效果好、精密度、准确度高，可用于中成药复杂化学环境中添加糖皮质激素的定性、定量分析。
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| 关 键 词： | 抗风湿中成药 醋酸泼尼松 HPLC法 |
Determination of Hormone Illegally Added in the Antirheumatism Drugs of Traditional Chinese Medicine |
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| Liu Jin-yan,Zhao Chun-jie and Wang Chao-zhong. Determination of Hormone Illegally Added in the Antirheumatism Drugs of Traditional Chinese Medicine[J]. , 2008, 9(6): 424-427 |
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| Authors: | Liu Jin-yan Zhao Chun-jie Wang Chao-zhong |
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| Affiliation: | Liu Jin-yan1,Zhao Chun-jie1,Wang Chao-zhong2(1.Shenyan Pharmaceutical University,Shenyang 111000,2.Qiqihaer Institute for Drug Control,Qiqihaer 161000) |
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| Abstract: | Objective To establish a method for detecting five kinds of hormones illegally added in the complicated antirheumatism drugs of Traditional Chinese Medition already.Methods:Ten kinds of antirheumatism drugs were chosen in random.They were determined by TLC and HPLC.Conclusion:The methed is simple,rapid and reliable for determining hormones in the complicated antirheumatism drugs,which is used as a qualitative and quntitive method. |
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| Keywords: | antirheumatism drugs Chinese medicine prednisone acetate HPLC |
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