| 人白细胞介素18cDNA编码区存在基因变异 |
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| 引用本文： | 王倩,刘世德,陈浩,宋国兴. 人白细胞介素18cDNA编码区存在基因变异[J]. 中国免疫学杂志, 2001, 17(1): 24-26 |
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| 作者姓名： | 王倩 刘世德 陈浩 宋国兴 |
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| 作者单位： | 中国协和医科大学 |
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| 摘 要： | 目的：为了获得中国人白细胞介素１８ｃＤＮＡ。方法：采用ＲＴ－ＰＣＲ方法从中国人７种组织标本中获取ＩＬ－１８ｃＤＮＡ。结果：７种组织中有６种组织标本ＩＬ－１８ｃＤＮＡ序列与报道序列存在有意义突变。结论：ＩＬ－１８基因在人体多种组织表达,且存在多态性。
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| 关 键 词： | 白细胞介素18 RT－PCR 基因克隆 序列分析 cDNA |
| 文章编号： | 1000-484X(2001)01-0024-03 |
Gene cloning and sequenceanalysis of human interleukin-18 mature peptide cDN |
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| WANG Qian,LIU ShiDe,CHEN Hao et al.Peking Union Medical school,Beijing. Gene cloning and sequenceanalysis of human interleukin-18 mature peptide cDN[J]. Chinese Journal of Immunology, 2001, 17(1): 24-26 |
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| Authors: | WANG Qian LIU ShiDe CHEN Hao et al.Peking Union Medical school Beijing |
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| Affiliation: | WANG Qian,LIU ShiDe,CHEN Hao et al.Peking Union Medical school,Beijing 100005 |
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| Abstract: | Objective:To acquire Chinese IL 18 mature peptide cDNA from adult PBMC,adult bone marrow cDNA libray,adult tonsil cDNA library,Embryonic cerebrum and cerebellum aged 3 months,Embryonic cerebrum and cerebellum aged 8 months.Methods:By RT PCR to aquire Chinese IL 18 mature peptide cDNA.Results:The six sequences of our seven species have basepair variation.Conclusion:The cDNA of Chinese IL 18 has polymorphism. |
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| Keywords: | Interleukin 18 RT PCR Gene clone Gene sequence analysis |
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