Docetaxel and mitomycin as second-line treatment in advanced non-small cell lung cancer |
| |
Authors: | J. Feliu G. Martín J. Castro A. Sundlov A. Rodriguez-Jaráiz E. Casado M. Lomas C. Madroñal A. Galán C. Belda M. Gonzalez-Barón |
| |
Affiliation: | (1) Servicio de Oncología Médica, Hospital Universitario La Paz, Paseo de la Castellana 261, 28046 Madrid, Spain;(2) Departments of Medical Oncology, Hospital Clínico, Salamanca, Spain;(3) Departments of Medical Oncology, Hospital San Pedro de Alcántara, Cáceres, Spain;(4) Departments of Medical Oncology, Hospital Infanta Cristina, Badajoz, Spain;(5) Departments of Medical Oncology, Clínica Corochán, Barcelona, Spain;(6) Departments of Medical Oncology, Hospital de Sagunto, Valencia, Spain |
| |
Abstract: | Purpose: To evaluate the feasibility, toxicity and efficacy of the combination of docetaxel and mitomycin C as second-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC). Patients and methods: Thirty-eight patients with histologically confirmed, locally advanced or metastatic NSCLC were included in this phase II trial. All patients had been previously treated with a platinum-based regimen. Treatment consisted of docetaxel (75 mg/m2) followed by mitomycin C (8 mg/m2) on day 1, every 21 days. Patients received a minimum of three courses unless progressive disease was detected. Results: A total of 190 courses of docetaxel-mitomycin C were administered (median five courses per patient). This combination was well tolerated with grade 3–4 toxicity experienced with the following frequency: neutropenia in five patients (13%), fatigue in four (11%), anaemia, thrombocytopenia, nausea/vomiting and peripheral neuropathy in one each (3%). Three of 38 patients had a partial response (8%, 95% confidence interval 2.6–21.6%), 14 patients (37%) experienced stabilization of disease and 21 (55%) had disease progression. Median time to progression was 3.6 months. Overall median survival was 10.4 months, with the 1-year actuarial survival rate being 35%. Conclusions: The addition of mitomycin C to docetaxel as second-line therapy in NSCLC is well tolerated but does not seem to improve the response rate. |
| |
Keywords: | Non-small cell lung cancer Docetaxel Mitomycin C Second-line chemotherapy |
本文献已被 PubMed SpringerLink 等数据库收录! |
|