Plasma vitamin D-binding globulin in vitamin D deficiency, pregnancy and chronic liver disease. |
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| Authors: | J M Barragry D Corless J Auton N D Carter R G Long J D Maxwell S Switala |
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| Affiliation: | Unit of Metabolism and Endocrinology, The London Hospital Medical College; Department of Geriatric Medicine, The Eastern, Hackney and St. Bartholomew''s Hospitals; Department of Medicine, The Royal Free Hospital; Departments of Child Health and Medicine, St. George''s Hospital Medical School, London U.K. |
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| Abstract: | Plasma concentrations of vitamin D-binding globulin were measured by radial immunodiffusion in healthy subjects, pregnancy, and during oestrogen therapy. Subjects with disorders of vitamin D metabolism (dietary deficiency, malabsorption, anticonvulsant therapy, chronic liver disease) were also studied. Neither sex nor age influenced the plasma vitamin D-binding globulin concentration in healthy subjects, but there was a significant increase in concentration during pregnancy and oestrogen therapy. Elevated levels were found in vitamin D deficient elderly but not younger subjects, while levels in subjects with chronic liver disease were significantly reduced. Normal levels of vitamin D-binding globulin were present in hypervitaminosis D and no vitamin D-binding globulin was detected in human milk. No correlation was observed between plasma 25-hydroxycholecalciferol levels and plasma vitamin D-binding globulin concentrations. |
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| Keywords: | Correspondence should be addressed to: Dr. J.M. Barragry Department of Metabolism and Endocrinology The London Hospital Whitechapel London El 1BB U.K.. |
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