Leptin inhibition of insulin secretion from isolated human islets |
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| Authors: | H. C. Fehmann P. Berghöfer D. Brandhorst H. Brandhorst B. Hering R. G. Bretzel B. Göke |
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| Affiliation: | (1) Clinical Research Unit for Gastrointestinal Endocrinology, Department of Medicine, Philipps-University of Marburg, Baldingerstrasse, D-35033 Marburg, Germany, DE;(2) University of Giessen, D-35083 Giessen, Germany, DE |
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| Abstract: | Leptin is a hormone produced and secreted from the adipose tissue. Its physiological actions include the regulation of satiety, food intake and energy balance. The production of leptin is increased by high insulin levels. Here, we demonstrate that leptin acts as an inhibitor of glucose-induced (20 mM) insulin secretion from isolated human islets. No effect was observed in the presence of lower glucose levels (2.8 and 10 mM glucose). The pancreatic β-cell might represent a target of a direct physiological action of leptin. We suggest the presence of an “adipo-insular axis” in which leptin mediates negative feedback from the adipose tissue to the endocrine pancreas. Received: 21 July 1997 / Accepted in revised form: 1 October 1997 |
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| Keywords: | Leptin Insulin secretion Endocrine pancreas β -cells |
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