原发性高血压、冠心病高危人群中血管紧张素Ⅱ受体基因多态性分析

目的探讨发生原发性高血压、冠心病与血管紧张素Ⅱ1型受体基因（ATIR）多态性与社区汉族人原发性高血压和冠心病的相互关系。方法用PCR技术检测AT1R基因3’端非翻译区（3’-UTR）A1166C多态性。并对100例健康体检者、203例原发性高血压（EH）患者、158例原发性高血压合并冠心病患者的AT1R基因A1166C多态性进行分析；用生化技术测定血脂水平。结果高血压患者中无论是否合并冠心病，其AT1R A1166C基因型分布均与对照组无显著性差异（P〉0．05）。高血压合并冠心病组与无冠心病组之间的AT1R基因型分布亦无显著差异（P〉0．05）。结论AT1R基因A1166C多态性与中国人高血压病发生及高血压患者是否易患冠心病无关。

Analysis on Angiotensin Receptor Polymorphism in High-risk Population with Primary Hypertension and Coronary Heart Disease

Objective To explore the relationship between angiotensin II type 1 receptor(AT_1R) gene polymorphism and essential hypertension(EH) complicated with coronary artery disease(CHD). Methods Angiotensin II type 1 receptor genotypes were investigated with PCR in 203 hypertensive patients,158 patients complicated with CHD and 100 healthy people. Results The distribution of AT_1R genotypes was of no significant difference between hypertension patients and health controls(P>0.05).No significant differences in genotype frequencies of AT_1R gene were found between EH complicated with CHD and those without CHD(P>0.05). Conclusion There is no relationship between AT_1R A1166C polymorphism and hypertension.AT_1R genotypes do not significantly influence the incidence of CHD in the hypertension.