Primary biliary cirrhosis and lichen planus |
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Authors: | F C Powell R S Rogers E R Dickson |
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Institution: | 1. From the Department of Dermatology and the Division of Gastroenterology and Internal Medicine, Mayo Clinic and Mayo Foundation, Rochester, MN |
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Abstract: | Lichen planus and primary biliary cirrhosis were seen in twenty-four patients. In seventeen patients, the cutaneous eruption followed the administration of D-penicillamine. In seven patients, lichen planus developed unrelated to therapy. Three of the latter group of patients were treated with D-penicillamine and had subsequent relapse or exacerbation of their preexisting lichen planus. The presence of lichen planus in patients with primary biliary cirrhosis and the propensity to develop this type of eruption while on D-penicillamine therapy are consistent with a graft-versus-host pathogenesis of primary biliary cirrhosis. Preexisting lichen planus should be regarded as a relative contraindication to the use of D-penicillamine in patients with primary biliary cirrhosis. |
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Keywords: | Reprint requests to: Frank C Powell M B c/o Section of Publications Mayo Clinic Rochester MN 55905 |
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