Lp-PLA2在顽固性高血压患者中的表达及其临床意义

目的 探讨顽固性高血压(RH)患者血浆中脂蛋白相关磷脂酶A2(Lp-PLA2)水平及其临床意义.方法 选择该院收治的120例RH患者为RH组,同时选择血压控制在正常范围内的120例原发性高血压患者为对照组;采用酶联免疫吸附法检测血浆Lp-PLA2水平,比较两组间的一般临床资料、Lp-PLA2水平及实验室生化指标,分析高...

The level of Lp-PLA2 in blood plasma and its clinical significance in patients with resistant hypertension

Objective To investigate the relationship between lipoprotein related phospholipase A2(Lp-PLA2)and resistant hypertension(RH)and its clinical significance.Methods A total of 120 cases of RH patients were selected as RH group and 120 essential hypertension patients whose blood pressure was controlled within the normal range were selected as control group.General clinical data,plasma Lp-PLA2 levels and biochemical indexes were detected between the two groups.At the same time,Lp-PLA2 levels were compared between different degree of patients with hypertension.Logistic regression analysis was used to analyze the influence factors of RH.Results Compared with the control group,the hypertensive course,24 h mean systolic blood pressure(24 h SBP),24 h mean diastolic pressure(24 h DBP),heart rate,rates of patients used diuretic,ACEI/ARB,CCB,high sensitivity C-reactive protein(hs-CRP),low density lipoprotein(LDL)in RH patients were significantly increased(P<0.05),while the rates of patients used statins was significantly decreased(P<0.05).Compared with the normal plasma Lp-PLA2 level group,patients in the elevated Lp-PLA2 level group had higher 24 h SBP,24 h DBP and rates of RH patients with the statistical differences(P<0.05).The higher the degree of hypertension(grades 1 to 3),the higher the plasma Lp-PLA2 level(P<0.05).Multivariate Logistic regression analysis showed that 24 h SBP,24 h DBP,hs-CRP,LDL and Lp-PLA2 were significantly correlated with the occurrence risk of RH(P<0.05).Pearson correlation analysis showed a positive linear correlation between Lp-PLA2 and 24 h SBP(P<0.05).Conclusion Level of Lp-PLA2 has shown abnormal elevation in patients with RH,the monitoring of level of Lp-PLA2 is helpful to the treatment of the disease.