醋酸泼尼松对浆细胞性乳腺炎患者血清中Treg/Th17比值及炎症因子的影响

目的 探讨醋酸泼尼松对浆细胞性乳腺炎患者血清中调节性T细胞(Treg)/辅助性T细胞17(Th17)比值及炎症因子的影响.方法 选取2017年10月至2019年10月重庆市妇幼保健院收治的浆细胞性乳腺炎患者80例,并将其随机分为观察组和对照组,每组40例.对照组患者给予哌拉西林舒巴坦钠治疗,观察组患者则给予醋酸泼尼松治...

Effect of Prednisone Acetate therapy on serum Treg/Th17 ration and inflammatory cytokines in patients with plasma cell mastitis

Objective To investigate the effects of Prednisone Acetate therapy on serum Treg/Th17 ratio and inflammatory cytokines in patients with plasma cell mastitis.Methods From October 2017 to October 2019,80 patients with plasma cell mastitis admitted to Chongqing Health Center for Women and Children were enrolled and randomly divided into observation group and control group,40 cases in each group.Patients in the control group were treated with Pailaxilinnashubatan hydrochloride while patients in the observation group was given Prednisone Acetate therapy.The effect of Prednisone Acetate therapy on serum Treg/Th17 ratio and inflammatory cytokines in patients with plasma cell mastitis were evaluated.Results After treatment,the proportion of Treg cells,the proportion of Th17 cells,the ratio of Treg/Th17 ratio and the levels of inflammatory cytokines(CRP,IL-6 and TNF-α)in two groups were decreased compared with before treatment(P<0.05).The proportion of Treg cells in the observation group was significantly lower than that in the control group,the proportion of Th17 cells and the Treg/Th17 ratio were significantly higher than that in the control group(P<0.05),and the level of inflammatory cytokines was significantly lower than that in the control group(P<0.05).Conclusion Prednisone Acetate therapy has a significant therapeutic effect on patients with plasma cell mastitis.It can obviously prevent inflammation and regulate the function of immune cells.