不同年龄多囊卵巢综合征患者性激素结合球蛋白与激素指标、血脂指标的相关性

目的 分年龄阶段探讨多囊卵巢综合征(PCOS)患者血清性激素结合球蛋白(SHBG)与空腹胰岛素(FINS)、硫酸脱氢表雄酮(DHEA-S)及血脂指标的相关性.方法 回顾性分析2017年1月1日至2019年8月30日在山东大学生殖医学研究中心就诊的3 349例PCOS患者的FINS、性激素和血脂指标,按照SHBG的参考值...

Correlation of sex hormone binding globulin with hormone indicators and blood lipid indicators in patients of different ages with polycystic ovary syndrome

Objective To investigate the correlation between serum sex hormone binding globulin(SHBG)and fasting insulin(FINS),dehydroepiandrosterone sulfate(DHEA-S)and blood lipid indicators in woman with polycystic ovary syndrome(PCOS)at different ages.Methods Retrospective analysis was performed on the data of sex hormones and blood lipid of 3349 PCOS patients treated at the Center for Research in Reproductive Medicine of Shandong University from January 1,2017 to August 30,2019.According to the lower limit of the reference value of SHBG concentration(32.4 nmol/L),the patients were divided into SHBG low-level group(SHBG<32.4 nmol/L,n=1780)and SHBG high-level group(SHBG≥32.4 nmol/L,n=1569),and each group was stratified by age(<25 years old,25—<30 years old,30—<35 years old,≥35 years old),the serum SHBG,FINS,DHEA-S and blood lipid indicators were detected and statistically analyzed.Results In the age range<25 years old,25-<30 years old,30-<35 years old,the FINS and DHEA-S concentrations in SHBG low-level group were significantly higher than those in SHBG high-level group(P<0.05),there was a decreasing trend with age on FINS in SHBG low-level group,on DHEA-S in the two groups(P<0.05).In the age range<25 years old,25-<30 years old,30-<35 years old,the concentrations of total cholesterol(TC),triacylglycerol(TG)and low density lipoprotein cholesterol(LDLC)in SHBG low-level group were significantly higher than those in SHBG high-level group(P<0.05).High density lipoprotein cholesterol(HDLC)level in SHBG low-level group was significantly lower than that in SHBG high-level group(P<0.05),the TC,TG,LDLC in the two groups showed an increasing trend with age(P<0.05).Correlation analysis showed that in the age range<25 years old,25-<30 years old,30-<35 year old,serum SHBG level positively correlated with HDLC level,and negatively correlated with FINS,DHEA-S,TC,TG and LDLC levels(P<0.05).Conclusion The level of SHBG in PCOS patients closely related to the levels of FINS and DHEA-S,and it also related to blood lipid indicators,change of SHBG concentration level could also be used as indicators of FINS,DHEA-S and blood lipid changes to provide important reference for early clinical diagnosis and timely treatment of PCOS.