胃肠道手术患者氧化应激反应对胃肠道功能恢复、切口愈合的影响及相关机制

目的 探讨胃肠道手术患者氧化应激反应对胃肠道功能恢复、切口愈合的影响及相关机制.方法 选取2018年8月至2019年8月在广西中医药大学第一附属医院外科行胃肠道手术的患者137例为手术组,另选取73例健康体检者为对照组.检测两组血清活性氧自由基(ROS)、D-乳酸、内毒素水平.比较手术组术前与对照组,以及术后不同胃肠道...

Effect and mechanism of oxidative stress response on recovery of gastrointestinal function and incision healing in patients undergoing gastrointestinal tract surgery

Objective To investigate the effect and mechanism of oxidative stress response on recovery of gastrointestinal function and incision healing in patients undergoing gastrointestinal tract surgery.Methods A total of 137 patients who underwent gastrointestinal tract surgery in the First Affiliated Hospital of Guangxi University of Chinese Medicine from August 2018 to August 2019 were selected as operation group.Another 73 healthy subjects underwent physical examination were selected as control group.The levels of serum reactive oxygen free radicals(ROS),D-lactic acid and endotoxin were detected in the two groups.Compared the serum ROS,D-lactic acid and endotoxin levels of patients with different gastrointestinal tract function scores,different surgical incision healing grade after surgery,and between operation group before operation and control group.Analyzed the correlation between serum ROS levels and D-lactic acid and endotoxin levels.Results The preoperative serum ROS,D-lactic acid and endotoxin levels in operation group were higher than those in control group,and the differences were statistically significant(P<0.05).With the increase of the gastrointestinal tract function scores,the patients′serum ROS,D-lactic acid and endotoxin levels gradually increased,and the differences were statistically significant(P<0.05).Compared with patients with grade A incision healing,the serum ROS,D-lactic acid and endotoxin levels of patients with grade B and C incision healing were significantly increased,and the differences were statistically significant(P<0.05).Compared with patients with grade B incision healing,the levels of serum ROS,D-lactic acid and endotoxin in patients with grade C incision healing were significantly increased,and the differences were statistically significant(P<0.05).Serum ROS levels positively correlated with D-lactic acid and endotoxin levels in patients with gastrointestinal tract function score 1,2 and 3 and with grade B and C incision healing(P<0.05).Conclusion Oxidative stress response in patients undergoing gastrointestinal tract surgery can delay the recovery of gastrointestinal tract function and affect the healing of surgical incision.