血清纤维蛋白胶凝素-3在2型糖尿病患者合并颈动脉粥样硬化中的应用价值

目的探讨血清纤维蛋白胶凝素-3(Ficolin-3)在2型糖尿病(T2DM)患者合并颈动脉粥样硬化(CAA)中的应用价值。方法选取2018年1月至2019年1月在该院内分泌科住院的初次诊断为T2DM的患者112例,根据是否合并CAA分为单纯T2DM组64例和T2DM合并CAA组48例。另选取同期健康体检者120例为对照组。比较3组基本资料、生化指标及血清Ficolin-3水平。比较不同CAA严重程度者血清Ficolin-3水平。使用Logistic回归分析T2DM患者合并CAA的危险因素。使用受试者工作特征曲线分析血清Ficolin-3水平对T2DM患者合并CAA的诊断效能。结果与对照组比较,单纯T2DM组、T2DM合并CAA组糖化血红蛋白(HbA1c)、总胆固醇、三酰甘油水平升高,血清Ficolin-3水平降低,差异均有统计学意义(P<0.05)。随着CAA严重程度分级升高,血清Ficolin-3水平逐渐降低,差异均有统计学意义(P<0.05)。饮酒≥10年、吸烟≥10年、体质量指数、HbA1c、低密度脂蛋白胆固醇水平升高是T2DM患者合并CAA的独立危险因素(P<0.05),血清Ficolin-3、高密度脂蛋白胆固醇水平升高是T2DM患者合并CAA的独立保护因素(P<0.05)。血清Ficolin-3诊断T2DM患者合并CAA的曲线下面积为0.599,灵敏度为70.83%,特异度为50.97%。结论血清Ficolin-3水平升高是T2DM患者合并CAA的独立保护因素,且其还对T2DM患者合并CAA具有一定的诊断价值。

Application value of serum Ficolin-3 in type 2 diabetes patients complicated with carotid atherosclerosis

Objective To investigate the application value of serum Ficolin-3 in patients with type 2 diabetes mellitus(T2DM)complicated with carotid atherosclerosis(CAA).Methods From January 2018 to January 2019,112 patients with T2DM diagnosed for the first time in the Department of Endocrinology of the hospital were selected and divided into simple T2DM group(64 cases)and T2DM complicated with CAA group(48 cases)according to whether they were complicated with CAA or not.Another 120 people underwent healthy physical examination during the same period were selected as control group.Compared the basic data,biochemical indexes and serum Ficolin-3 levels of the 3 groups.Compared the serum Ficolin-3 levels in the subjects with different CAA severity.Logistic regression was used to analyze the risk factors of T2DM patients complicated with CAA.The receiver operating characteristic curve was used to analyze the diagnostic efficacy of serum Ficolin-3 levels in T2DM patients complicated with CAA.Results Compared with control group,the levels of glycosylated hemoglobin(HbA1c),total cholesterol and triacylglycerol in simple T2DM group and T2DM complicated with CAA group increased,and the serum Ficolin-3 level decreased,the differences were statistically significant(P<0.05).As the severity of CAA increased,serum Ficolin-3 levels gradually decreased,and the differences were statistically significant(P<0.05).Drinking≥10 years,smoking≥10 years,body mass index,HbA1c,low density lipoprotein cholesterol levels increased were the independent risk factors of T2DM patients complicated with CAA(P<0.05),and serum Ficolin-3,high density lipoprotein cholesterol levels increased were the independent protective factors of T2DM patients complicated with CAA(P<0.05).The area under the curve of serum Ficolin-3 in the diagnosis of T2DM patients complicated with CAA was 0.599,the sensitivity was 70.83%,and the specificity was 50.97%.Conclusion The increase of serum Ficolin-3 level is an independent protective factor for T2DM patients complicated with CAA,and it also has a certain diagnostic value for T2DM patients complicated with CAA.