FGF23、sclerostin蛋白、fetuin-A与慢性肾脏病患者血管钙化的相关性研究

目的 探讨成纤维细胞生长因子23(FGF23)、骨硬化蛋白(sclerostin蛋白)、胎球蛋白A(fetuin-A)与慢性肾脏病患者血管钙化的相关性.方法 选取2018年2月至2020年2月该院诊治的200例慢性肾脏病患者,根据冠状动脉有无钙化分为观察组(102例)与对照组(98例),比较两组FGF23、sclero...

Correlation between FGF23 ,sclerostin and fetuin-A with vascular calcification in patients with chronic kidney disease

Objective To investigate the correlation between fibroblast growth factor 23(FGF23),bone sclerostin and fetuin-A with vascular calcification in the patients with chronic kidney disease.Methods Two hundreds patients with chronic kidney disease diagnosed and treated in this hospital from February 2018 to February 2020 were selected and divided into the observation group(102 cases)and control group(98 cases)according to whether existing the vascular calcification.The levels of FGF23,sclerostin and fetuin-A levels were compared between the two groups.The efficiency of FGF23,sclerostin and fetuin-A for diagnosing vascular calcification was evaluated.Among them,the observation group was divided into 3 groups according to the coronary arterial calcification score,34 cases in each group.The levels of FGF23,sclerostin and fetuin-A were compared among different calcification groups.The correlation between different vascular calcification degrees with FGF23,sclerostin and fetuin-A was analyzed.The efficiency of FGF23,sclerostin and fetuin-A for diagnosing severe vascular calcification was evaluated.Results The FGF23 and sclerostin levels of the observation group were higher than those of the control group,while the fetuin-A level was lower than that of the control group(P<0.05).The receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)values of FGF23,sclerostin,and fetuin-A were 0.990,0.967 and 0.722 respectively(P<0.05).In different calcification groups,the FGF23 and sclerostin levels were the mild calcification groupmoderate calcification group>severe calcification group,and the differences were statistically significant(P<0.05).The Spearman analysis showed that the vascular calcification severity in the patients with chronic kidney disease was positively correlated with FGF23 and sclerostin(P<0.05),and negatively correlated with fetuin-A(P<0.05).The AUC values of FGF23,sclerostin and fetuin-A in the patients of the severe calcification group were 0.917,0.926 and 0.749 respectively(P<0.05).Conclusion The FGF23,sclerostin and fetuin-A levels are correlated with the severity degree of vascular calcification in the patients with chronic kidney disease.The above indicators can serve as the reference indicators of clinical diagnosis for vascular calcification.